Antineoplastic agents hormonal

Considering all aspects, sex hormones, antibacterials, and antineoplastic agents were identified by Christensen as the three most relevant groups of chemicals concerning their potential human risk as a consequence of drug exposure via the environment [10]. Immunochemical methods for hormones and antibiotics have already been discussed above. In this section we will describe methods based on the use of antibodies for the analysis of analgesics, NSAIDs, and cytostatic agents. 

Mechanism of Action A hormone and antineoplastic agent that suppresses the release of luteinizing hormone from the anterior pituitary gland by inhibiting pituitary function. Therapeutic Effect Shrinks tumors. Also increases appetite by an unknown mechanism. 

Ordentlich, P., Yan, Y., Zhou, S. and Heyman, R.A. (2003) Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurrl. The Journal of Biological Chemistry, 278, 24791-24799. 

Give a comprehensive aeeount of hormones that are potent as antineoplastic agents. Support your answer with suitable examples. 

Mechanism of Action. Chlormadinone acetate is an orally active progestogen having distinct and potent antiandrogenie aetivity, which has been used in eombination as an oral contraceptive. It serves as a hormonal antineoplastic agent. 

Antineoplastic Agent. Synthetic hormone. Stops production of testosterone in men. Decreases production of estradiol in women. 

Biodegradable hydrogels have also been developed for use in controlled drug delivery as carriers of biologically active materials such as hormones, enz5mes, antibiotics, antineoplastic agents, and cell suspensions. Temporary preservation of functional properties of a carried species, as well as the controlled release of the species into local tissues or systemic circulation, have been achieved. 

In addition to antineoplastic, cytotoxic agents, there are cancer therapeutic or preventative drugs that are intended to be given on a chronic basis. This includes chemopreventatives, hormonal agents, immunomodulators, and so on. The toxicity assessment studies on these will more closely resemble those of more traditional pharmaceutical agents. Chronic toxicity, carcinogenicity, and Ml developmental toxicity (ICH A-B, C-D, E-F) assessments will be required. For a more complete review, the reader is referred to DeGeorge et al. (1998). 

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