Antimicrobial therapy principles

Identify and apply five major principles of patient education and monitoring response to antimicrobial therapy. 

These extended case studies complement the basic information presented in Chapters 1 to 40. They reinforce basic principles of pharmacology, such as the role of patient factors in empiric antimicrobial therapy Most of the cases provide clinical information obtained from a single patient some cases describe a composite of typical features derived from several patients. These cases illustrate simple pharmacologic principles, such as consideration of kidney function in drug dosing—concepts useful in answering examination questions, and in the clinics. 

Prescott, J.F. Baggot, J.D. Principles of antimicrobial drug disposition antimicrobial drug use in bovine mastitis. In Antimicrobial Therapy in Veterinary Medicine, 2nd Ed. Iowa State University Press Ames, Iowa, 1993 37-60, 553-561. 

Since the 1980s, the specialty area of infectious diseases within pharmacy practice has evolved into a distinct discipline that is directed at providing optimum antimicrobial therapy to patients. The pharmacist is uniquely qualified to apply therapeutic, pharmacokinetic, and pharmacodynamic principles to antimicrobial therapy. These skills serve to complement rather than compete with the roles of infectious diseases physicians. Infectious diseases pharmacists are employed in private and teaching hospitals, clinics, academia, and industry. Literature that document the positive impact of the infectious diseases pharmacist on patient outcomes is now being published. 

B. Prindples of Antimicrobial Therapy Antimicrobial therapy in established infections is guided by the following principles ... 

The principles of antimicrobial therapy are outlined on the following pages. Key issues to consider when prescribing an antimicrobial regimen include ... 

Baggot JD, Principles of antimicrobial drug bioavailability and disposition, in Gigubre S, Prescott JF, Baggot JD, Walker RD, Dowling PM, eds.. Antimicrobial Therapy in Veterinary Medicine, 4th ed., Ames, lA,Blackwell, 2006, pp. 45-79. 

Chambers HP, General principles of antimicrobial therapy, in Brunton LL, Lazo J, Parker K, eds., Goodman and Gilman s Pharmacological Basis of Therapeutics, 11th ed., McGraw-Hill, New York, 2006, pp. 1095-1111. 

Nicolau DP, Nightingale CH, Quintilian R. Continuous infusion 3-lactams a pharmacodynamic approach. Infect Dis Clin Pract 1996 5(7) 432-434. Quintiliani R, Nicolau DP, Nightingale CH. Pharmacokinetic and pharmacodynamic principles in antibiotic usage. In Infectious Diseases and Antimicrobial Therapy of the Ears, Nose and Throat. Philadelphia WB Saunders, 1997 48-55. Niederman MS. Principles of antibiotic use and the selection of empiric therapy for pneumonia. In Fishman AP, Elias JA, Fishman JA, Grippi MA, Kaiser LR, Senior RM, eds. Fishman s Pulmonary Disease and Disorders. 3rd ed. New York McGraw-Hill, 1998 1939-1957. 

The following principles, many of which apply to drug therapy in general, are a guide to good practice with antimicrobial agents. 

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