Pharmacology principles

Outline the pharmacologic principles for agents used to treat colon cancer. 

Buxton, D. A. (1972) Behavioral actions of some substituted amphetamines. In Progress in Brain Research Biochemical and Pharmacological Principles Underlying Behavior, edited by P. B. Bradley and R. W. Brimblecombe, pp. 171-180. Elsevier, Amsterdam. 

John C. Krantz, Jr., and C. Jelleff Carr, The Pharmacologic Principles of Medical Practice, Williams Wilkins Co., Baltimore, Md., ed., 1954, p. 64. 

Aviado DM. 1972. Chloroform. In Krantz and Carr s pharmacologic principles of medical practice, eighth edition. Baltimore, MD Waverly Press, Inc, 250-261. 

Schatzberg AF. Pharmacological principles of antidepressant efficacy. Hum Psychopharma-col 2002 17(Supplement 1) S17-S22. 

Prescribe medications according to pharmacologic principles, favoring long-acting formulations Be willing to stop unsuccessful therapy and try a different approach... 

In about 975 A.D. the Persian pharmacist Abu Mansur Muwaffaq wrote his Book of Pharmacological Principles, in which he described for the first time the use of the plaster of Paris bandage for bone fractures (76). 

Figure 9.2 illustrates the various inputs and outputs of a model built to demonstrate the 5-year results of therapy with entacapone (Comtan1 ), which represents a novel pharmacological principle used in combination with levodopa therapy. The inputs list the data fed into the model. The clinical effects of the therapy are taken from the clinical trials. The costs by disease stage are defined as costs for >25% OFF time per day (severe stage) and costs for <25% OFF time per day (less severe) and are taken from literature sources. Patient preference data (used to calculate QALYs) for these two disease stages are taken from a separate study of patient preferences. The outputs of the model list some of the more common uses of the model ... 

The pharmacologic principles of ligand-receptor interaction predict that the level of receptor should affect dose-response curves for enzyme induction. In rodent systems, several endogenous and exogenous factors have been shown to alter levels of various receptors or other components in the induction pathway. 

These extended case studies complement the basic information presented in Chapters 1 to 40. They reinforce basic principles of pharmacology, such as the role of patient factors in empiric antimicrobial therapy Most of the cases provide clinical information obtained from a single patient some cases describe a composite of typical features derived from several patients. These cases illustrate simple pharmacologic principles, such as consideration of kidney function in drug dosing—concepts useful in answering examination questions, and in the clinics. 

If you are wondering how the pharmacology principles you are studying will apply to real-life patients, this book is just what you need. Use it during your coursework to aid in understanding of basic science concepts. Also a great review as you prep for exams and your work on the wards. 

Basic pharmacologic principles apply as much to drug interactions as to drug actions. Each kinetic property—absorption, distribution, metabolism (biotransformation), and excretion—is potentially affected by the presence of coadministered medications. Drug interactions follow a variable time-course pattern, from immediate to delayed. Consequently, it is important to remember that several weeks may elapse before the effects of an interactive combination are evident. 

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