Antimicrobial agents antifungal compounds

Of these, noxythiolin (N-hydroxy-Af-methylthiourea) has the greatest pharmaceutical use as an antimicrobial agent. The compound is supplied as a dry powder and on aqueous reconstitution slowly releases formaldehyde and iV-mefhylthiourea. Antimicrobial activity is considered to be due to both the noxythiolin molecule and the released formaldehyde. Noxythiolin is used both topically and in accessible body cavities as an irrigation solution and in the treatment of peritonitis. The compound has extensive antibacterial and antifungal properties. 

Silver and its compounds have long been used as antimicrobial agents in medicine. The mechanisms of silver toxicity as they relate to human exposure to pharmaceuticals have been reviewed (328). Silver is active at low concentrations and has a low toxicity. The practice of instilling the eyes of infants with 1% of AgN03 solution immediately after birth is still common in some countries, for prevention of opthalmia neonatorum (329). Silver sulfadiazine 77 is clinically used as a topical antimicrobial and antifungal agent and applied as a cream to prevent bacterial infections in cases of severe burns. It is an insoluble polymeric compound and releases Ag(I) ions slowly. 

Petersen BH, Green L, Steimel L, Hyslop D, Current WL. Use of flow cytometry for deter mination of minimal exposure time for effective antifungal activity of LY303366 and other antifungal compounds. Thirty-third Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans, October 17-20,1993 Abstract 362. 

Hajdu R, Thompsot R, White K, Stark-Murphy B. Kropp H. Comparative phaimacokinet ics of three water Soluble analogues of the lipopeptide antifungal compound L 688,786 in mice and rhesus monkeys. Thirty-third Interscicnce Conference on Antimicrobial Agents and Chemotherapy, New Orleans, October 17-20. 1993 Abstract 357. 

In addition to the use of alkyl gallates as food and cosmetic additives, the multifunctional action of these compounds and their potential application for other purposes has been widely investigated, as described below. Some of these applications, which are discussed below, involve their use as enzymatic inhibitors, as anticancer, antifungal and antimicrobial agents, and as additives in nonfood and noncosmetic industries (Figure 14.2). These applications are mainly based on the antioxidant and prooxidant properties of these compounds, which, together with their potential toxicity, are also discussed below. 

Chapter 4 - Propolis has been used for as a traditional medicine in Eastern Europe as an antifungal, antimicrobial, antiviral, anti-inflammatory, and anticarcinogenic agent. The author isolated three cinamic acid derivatives and one flavanol derivative from Brazilian propolis and determined their structures by spectroscopic analysis. Results were assayed, the anticancer drug potential of these compounds to identify new drug candidates, by determining the... 

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