Antimicrobial activity silicone

Gottenbosa B, Henny C, van der Meia, Klatterb F, Nieuwenhuisb P, and Busscher HJ. In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber. Biomaterials, 2002, 23, 1417-1423. 

Silicon Containing Amines with Insect-Repellent and Antimicrobial Activity... 

Gottenbos, Bart, van der Mei, Henny, Klatter, Flip, nieuwenhiiis, Paul and Henk J. Busscher. In vitro and In vivo Antimicrobial Activity of Covalently Coupled Quaternary Ammonium Silane Coatings on Silicone Rubbei, BioMaterials, March 2002 1417-23. 

Boswald, M., Girisch, M., GreU, J., Spies, T., Stehr, K., Krall, T., Guggenbichler, J.-P., 1995. Antimicrobial activity and biocompatibUity of polyurethane and silicone catheters containing low concentrations of silver a new perspective in prevention of polymer-associated foreign-hody-infections. Zentralhlatt fiir Bakteriologie 283,187-200. 

Ladani NK, Patel MP, Patel RG (2010) A convenient one-pot synthesis of some new 3-(2-phenyl-6-(2-thienyl)-4-pyridyl)hydroquinolin-2-ones under microwave irradiation and their antimicrobial activities. Phosphorus Sulfur Silicon 185 658-662... 

Lee and Mukherjee employed the dienyne metathesis protocol for the synthesis of the C1-C19 fragment of (—)-cochleamycin A (246, Scheme 24.59), which was isolated by the Kirin Brewery group from Streptomy-ces sp. to exhibit antitumor and antimicrobial activities The metathesis precursor 242 was prepared by stepwise reactions of trialkynylsilane 240 with alcohols 239 and 241. Exposure of 242 to [Ru]-II forms bicyclic siloxane 243, and removal of the silicon tether by TBAF afforded E,Z-1,3-dienediol 244 in 61% yield. The subsequent manipulations to 245 were carried out effectively. 

Processing of textile materials by silicones also imparts antimicrobial properties to these clothes. Some authors state that textile material sizing by water repellents imparts them sufficient antimicrobial activity. Water repellency of materials may reduce the adverse impact of microoiganisms, because the quantity of adsorbed moisture is reduced. However, Hydrophobic finishing itself may not fully ehminate the adverse effect of microorganisms. Therefore, antimicrobial properties imparted to some textile materials during silicone finishing may be related to application of metal salts as catalysts, such as copper, chromium and aluminum. 

More recently, Lee et al. have also employed this strategy for the construction of the B/Z-1,3-butadiene motif required for the synthesis of (—)-cochleamycin A using a biomimetic type transannular Diels-Alder reaction, (Figure 8.10) [38]. The enantiomer exhibits antimicrobial activity against Gram-positive bacteria and has modest cytotoxic activity. The unsymmetrical bis-alkoxyalkynylsilane 85 was prepared as a mixture of diastereoisomers at silicon by the addition of the secondary alcohol 84 to the bis-alkynylsiloxane 83 (Scheme 8.16). Although the... 

Examples of preservatives are phenylmercuric nitrate or acetate (0.002% w/v), chlorhexidine acetate (0.01 % w/v), thiomersal (0.01 % w/v) and benzalkorrium chloride (0.01 % w/v). Chlorocresol is too toxic to the comeal epithehum, but 8-hydroxyquinoline and thiomersal may be used in specific instances. The principal considerahon in relation to antimicrobial properties is the activity of the bactericide against Pseudomonas aeruginosa, a major source of serious nosocomial eye infections. Although benzal-konium chloride is probably the most active of the recommended preservatives, it cannot always be used because of its incompatibility with many compounds commonly used to treat eye diseases, nor should it be used to preserve eye-drops containing anaesthetics. Since benzalkonium chloride reacts with natural mbber, silicone or butyl rabber teats should be substituted. Since silicone mbber is permeable to water vapour, products should not be stored for more than 3 months after manufacture. As with all mbber components, the mbber teat should be pre-equilibrated with the preservative prior to... 

Antimicrobial, in Particular Antifungal, Activity of Orqanomet-allic Compounds of Silicon, Germanium, Tin and Lead. 

The use is discussed of Vanquish biocides from Zeneca Biocides. They are antimicrobials developed specifically for the plastics industiy, and have a broad spectmm of activity in a wide range of polymers, including PVC, polyurethanes, polyolefins and silicones. Features and properties of the products are described, and their application in silicone, polyurethane and PVC products is examined. 

Many examples have been reported on the biosurfactants potential as anti-adhesive coatings. The amount of biofilm formed by Salmonella typhimurium. Salmonella enterica, Escherichia coli and Proteus mirabilis in vinyl urethral catheters coated with surfactin was reduced as compared to the uncoated controls [124], Also, biosurfactants from probiotic lactobacilli successfully prevented the adhesion of uropatho-gens, and subsequent urogenital infections [19-21, 125], Biosurfactants from lactic acid bacteria (Streptococcus ther-mophilus A and Lactococcus lactis 53) were effectively used to avoid microbial colonization of silicone rubber voice prosthe-ses, thus their premature failure [26,27]. These bacterial [22] and Lactobacillus paracasei [126] biosurfactants were found to possess antimicrobial and anti-adhesive activity against... 

KATHON LX and KATHON LX 1.5% are antimicrobial products offered for use as preservative in latices containing acrylic, vinyl acetate-acrylic, polyvinyl acetate, styrene-butadiene, silicone, and other polymers. The active ingredients are effective at low concentrations against fungi and bacteria and are highly resistant to the inhibitory effects of most organic and inorganic compounds. 

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