Antihypertensive drugs names

Antihypertensive drug name and dose is associated with compelling indications which are based on benefits from outcome studies or clinical guidelines. For example, the drug class aldosterone antagonists have eplerenone dosed at 25-50 mg per day which is indicated for heart failure patients after an Ml and supported by the EPHESUS trial. 

Phenylephrine is a specific a-agonist with very little effect on p-receptors The other name for this drug, a brand name, is Neosynephrine and it can be found in nasal decongestant sprays and as a dilator in opthamology. It can also be used with the antihypertensive drug phenoxybenzamine and the smooth muscle relaxant papaverine in order to treat impotence in males. 

This compound, sold under the trade name Inderal , was the second most widely prescribed drug in the early 1980s. It is used as an antianginal and antihypertensive drug. 

Pharmaceutical Products. Rlic ne-Poulenc offers a flaked technical-grade vanillin, Vaniltek, to be used in pharmaceutical applications. The single largest use for vanillin is as a starting material for the manufacture of an antihypertensive drug having the chemical name of Methyldopa or L-3-(3,4-dihydroxyphenyl)-2-methylalanine. 

Clonidine, hydralazine, methyl dopa and diazoxide and potent antihypertensive drugs used as cardiovascular drugs. Give the synthesis of any two named compounds. 

Discuss the mode of action of some antihypertensive drugs being employed and cardiovascular drugs . Give their structures and chemical names. 

The manufacturers of alfuzosin and prazosin warn that patients receiving antihypertensive drugs (the manufacturers of prazosin specifically name the ACE inhibitors) are at particular risk of developing postural hypotension after the first dose of alpha blocker. 

The manufacturer notes that smaller doses of sodium nitroprusside might be required in patients receiving antihypertensive drugs. In any event the required dose varies considerably between patients and so should be titrated to effect. When used for controlled hypotension during anaesthesia, the hypotensive effect of other drugs, particularly anaesthetics, should be remembered. They name halothane and enflurane. 

A 55-year-old patient has been referred to you. She complains about a skin rash and a cough. In the course of history taking, she tells you that she takes high blood pressure medication but she doesn t remember the name. You suspect a drug toxicity. Which of the following antihypertensive agents is the patient most likely taking ... 

Baroreceptor reflexes a fall in blood pressure evokes reflex activity of the sympathetic system, causing increased peripheral resistance and cardiac activity (rate and contractility). Therefore, whenever high blood pressure is proving difficult to control and whenever a number of antihypertensives are used in combination, the drugs chosen should between them act on all three main determinants of blood pressure, namely ... 

ANG II is also known to induce release of catecholamines from the adrenal medulla and to suppress the reflex inhibition of the heart rate, with the latter probably the inhibiting vagal (cholinergic) neurons to the heart. This has a specific clinical effect that is useful in the use of ACE inhibitors as antihypertensives (see later) namely, the absence of reflex tachycardia seen with other types of blood pressure-lowering drugs such as a-blockers, diazoxide, hydralazine, and ganglionic blockers. 

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