Antihypertensive agents properties

Triamterene is also a diuretic with distal tubule action and potassium retaining properties. It is not generally used alone as an antihypertensive agent. 

Yohimbe bark Centrally active antihypertensive agents Yohimbine (a major alkaloid in yohimbe bark) may antagonize guanabenz and the methyldopa metabolite through its oj-adrenoceptor antagonistic properties. 

The vasodilating properties of captopril or hydralazine (antihypertensive agents) are mediated by the formation of EDRF or prostaglandin, or both. On the other hand, the vasodilating properties of nitroprusside (an antihypertensive agent) result directly from the formation of cyclic GMP. 

Bretylium was first introduced as an antihypertensive agent. It interferes with the neuronal release of catecholamines but also has direct antiarrhythmic properties. 

Diabetes is the most frequent cause of end-stage renal disease. Hypertension, which is common among patients with type 2 diabetes, accelerates the development and progression of renal disease. Early and tight blood pressure control in diabetic patients, preferably with antihypertensive agents that have proven reno-protective properties, is therefore essential to minimize loss of kidney function. Several controlled clinical trials have investigated and proved the beneficial effects of ARBs on type 2 diabetic nephropathy [10-14]. 

Compounds 696 and 697 are further examples for antihypertensive agents, in which a cyclopropylamino group is involved. Diuretic, hypnotic and anorectic effects have been claimed for 697, too . Aminocyclopropanes with tranquillizing properties or as part of a tranquillizing system have been reported. Antiinflammatory activity was found for compounds 698 and 699 for further examples see Refs 77, 391. Analgesic effectiveness has been established for some... 

An interesting example of the development of a useful drug by molecular modifications of a related lead is to be found in another chemical class of antihypertensive agents epitomized by guanethidine. Maxwell et al. (21) relate the development of this drug to the observation of certain pharmacological characteristics of an earlier chemical relative, SU-4029. The preparation and properties of a variety of related compounds have been presented by Mull... 

In conclusion, the incorporation of an acetylenic moiety into a benzylamine structure conferred completely novel biochemical and therapeutic properties on an otherwise inert phenylalkylamine. Outstanding in this respect are the potent MAO-inhibitory, antihypertensive, and antidepressant effects of this new drug. The potent autonomic side effects normally encountered with the ganglionic blocking type antihypertensive agents are much less pronounced with this drug and a definite advance has been scored toward achieving selectivity of action. 

Indenolol is a new antihypertensive agent with beta,-adrenoceptor antagonist and beta2-adrenoceptor agonist properties. 

A reduction of atherosclerotic complications is the major objective of long-term therapy with antihypertensive agents [78], Several studies were carried out on the effects of oleic acid and its congeners, such as elaidic and stearic acids, and on the structural properties of membranes. 

It is an antihypertensive agent with P-adrenoceptor blocking actions similar to those of propranolol hydrochloride. Besides, it possesses a-adrenoceptor blocking properties which lower blood pressure by decreasing peripheral vascular resistance. 

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