Antihelmintics

Polysubstituted imidazo[4,5-/]quinolines were prepared and evaluated by Spencer and Alaimo, but also by other authors for possible antihelmintic activity... 

An imidothiazole has proved to be quite active as a broad-spectrum antihelmintic agent. Alkylation of 2-aminothiazoline (SI)... 

Antihelmintic (Anthelmintic). An agent that is useful in the control of parasitic worms. 

Other examples of enantioseparations include the separation of the antihelmintic drug, prazinquatel [35], which used a 4-column SMB system composed of columns of 12.5 mm i.d. packed with CTA and with methanol as the eluent. Ikeda and Murata separated the enantiomers of (3-blockers [36]. 

Antifungals Biphenamine Ciclopirox Econazole Ethonam Antihelmintics Miconazole To1indate Tolnaftate... 

Thiabendazole is an antihelmintic drug with a broad spectrum of action. Although the details of its mechanism of action are not conclusively known, it seems likely that its action is mediated by the inhibition of a specific enzyme of helminthes—fumarate reductase. Thiabendazole is active with respect to most nematode infections, including... 

AntihBiminticS Flubendazole was launched as an antihelmintic. It seems to have a mode of action close to that of benzimidazole derivatives used as antihelmintics mebendazole, albendazole), which are reported to block the capture of glucose by the parasite (Figure 8.23). 

Heterocyclic amines have also been used for aminolysis. Subsequent cyclization of the acylamino amides leads to imidazolones that show a diverse range of biological activities as antibacterial, antifungal, antiviral, antihelmintic, and anti-Parkinsonian agents, as well as central nervous systems (CNS) stimulants. 

Hydrazides have also been used as nucleophiles for ring opening to give the corresponding bis(acylhydrazides) 540. ° Subsequent cyclodehydration of 540 leads to the 4-alkylidene(arylidene)imidazolones 541 that have been evaluated as anticonvulsant, antihelmintic, antibacterial, antifungal, antiviral, and antitubercular agents (Scheme... 

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