Antihelmintic activity

Polysubstituted imidazo[4,5-/]quinolines were prepared and evaluated by Spencer and Alaimo, but also by other authors for possible antihelmintic activity... 

Scheme 3 shows the synthesis of (-)-cinnamodial (ugandensidial) (18), the warburganal-related dialdehyde, from the drimenol (2) [25]. Cinnamodial also has a bitter taste [3], and possesses antimicrobial, antifeedant, piscicidal and antihelmintic activities [3, 4]. Cinnamodial (18) has been simultaneously isolated from Cinnamosma fragrans [26] and from Warburgia ugandensis [27], and then from other plants [4],... 

Combinatorial chemistry has become a powerful methodology for the construction of new compounds. Natural products, however, also have enormous potential as a source of new compounds. In particular, numerous useful microbial products have been isolated as antibiotics, herbicides, fungicides and enzyme-inhibitors. Moreover, microorganisms have provided various compounds with diverse bioactivities, such as immunomodulatory, antitumor and antihelmintical activities [1]. 

Ionescu et al. exhibited that T. vulgare showed antihelmintic activity. Ether extract, essential oils and (3-thujone isolated from T. vulgare were found as active principles and toxic doses were recorded [183]. 

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