Antidotes for

Phenol should not be allowed to come into contact with the skin for it causes painful burns. The best antidote for phenol burns is a saturated solution of bromine in glycerine if all undi.ssolved bromine is allowed to settle out before the solution is used, there is no danger of bromine burns. Lime water may also be employed. 

There is no specific antidote for acrolein exposure. Treatment of exposure should be directed at the control of symptoms and the clinical condition. Most of the harmful effects of acrolein result from its highly irritating and corrosive properties. 

Other Uses. Other appHcations for sodium nitrite include the syntheses of saccharin [81-07-2] (see Sweeteners), synthetic caffeine [58-08-2] (22), fluoroaromatics (23), and other pharmaceuticals (qv), pesticides (qv), and organic substances as an inhibitor of polymerization (24) in the production of foam blowing agents (25) in removing H2S from natural gas (26) in textile dyeing (see Textiles) as an analytical reagent and as an antidote for cyanide poisoning (see Cyanides). 

Because of its extreme insolubiUty, barium sulfate is not toxic the usual antidote for poisonous barium compounds is to convert them to barium sulfate by administering sodium or magnesium sulfate. In medicine, barium sulfate is widely used as an x-ray contrast medium (see Imaging TECHNOLOGY X-RAY technology). It is also used in photographic papers, filler for plastics, and in concrete as a radiation shield. Commercially, barium sulfate is sold both as natural barite ore and as a precipitated product. Blanc fixe is also used in making white sidewall mbber tires or in other mbber appHcations. 

In most situations, adequate, usuaHy forced, ventilation is necessary to prevent excessive exposure. Persons who drink alcohol excessively or have Hver, kidney, or heart diseases should be excluded from any exposure to carbon tetrachloride. AH individuals regularly exposed to carbon tetrachloride should receive periodic examinations by a physician acquainted with the occupational hazard involved. These examinations should include special attention to the kidneys and the Hver. There is no known specific antidote for carbon tetrachloride poisoning. Treatment is symptomatic and supportive. Alcohol, oHs, fats, and epinephrine should not be given to any person who has been exposed to carbon tetrachloride. FoHowing exposure, the individual should be kept under observation long enough to permit the physician to determine whether Hver or kidney injury has occurred. Artificial dialysis may be necessary in cases of severe renal faHure. 

Effective antidotes for use in an emergency are not common. Examples include ... 

Sodium nitrite (NaNOg) is used by emergency medical personnel as an antidote for cyanide poisoning (for this purpose, it must be administered immediately). Based on the discussion of cyanide poisoning in Section 21.10, suggest a mechanism for the life-saving effect of sodium nitrite. 

Therapeutic Function Cholinesterase reactivator (antidote for nerve gas) Chemical Name 2-[(Hydroxyimino)methyl] -1-methylpyridinium chloride Common Name 2-PAM chloride Structural Formula ... 

Dantrolene is an antidote for MH, which inhibits the CICR activity. Action of dantrolene may be isoform specific (less effective on RyR2), Ca2+-dependent (more effective at a lower Ca2+ concentration), and temperature-dependent (more effective at 37°C than at 25°C). 

Antidote for digoxin Hypokalemia, re-emergence of toxicity artial fibrillation or CHF... 

This chapter is concerned therefore with studies of the mechanism of action of palytoxin, how it produces its lethal effects, as well as attempts to develop an antidote for this form of poisoning. 

Inhalation and dermal absorption mustards no antidote. For lewisite and ewisite/ mustard lmixtures British Anti-Lewisite (BAL or Dimercaprol) IM (rarely available). Thermal burn therapy supportive care (respiratory support and eye care). 

Thirty-five to eighty-seven percent of the patients studied received antiparkinson drugs. Compared to other countries, Japan and Singapore used the most of these antidotes for drug-induced extrapyramidal symptoms. This is most likely related to the frequent use of high-dosage antipsychotic drugs and poly-antipsychotics (see Table 12.3). 

There is no proven antidote for hydrogen sulfide poisoning. Treatment consists of supportive measures such as evaluating and supporting airway, breathing, and circulation (ATSDR 1994). Sodium nitrite may or may not be an effective antidote, but if proper precautions in administration are observed, intravenous administration of sodium nitrite may help some hydrogen sulfide poisoned persons (Hall 1996 Hall and Rumack 1997). Hyperbaric oxygen therapy is controversial, but it may be effective for patients not treated successfully by other measures (ATSDR 1994). 

Beck JF, Bradbury CM, Connors AJ, et al. 1981. Nitrite as an antidote for acute hydrogen sulfide intoxication Am Ind Hyg Assoc J 42 805-809. 

There is no antidote for exposure to these agents. Treatment consists of symptomatic management of lesions. Eye lesions should be treated by saline irrigation and coating the follicular margins with petroleum jelly to prevent sticking. 

For cyanide and cyanogen, antidote should be administered as soon as possible. The Lilly Cyanide Antidote Kit contains amyl nitrite, sodium nitrite, and sodium thiosulfate. Cobalt edentate or 4-dimethylaminophenol are alternative antidotes for cyanide poisoning. Benzodiazepines or barbiturates may be required to control severe seizures. 

There is no antidote for exposure to these agents. Enforce rest as even minimal physical exertion may shorten the clinical latent period. Asymptomatic individuals suspected of exposure to pulmonary agents should be monitored for possible complications caused by... 

Complexes of beryllium with 1,2-dihydroxybenzene (catechol) and its more soluble sulfonate derivatives (188, 198, 251-256) have been investigated with particular reference to their possible use as antidotes for beryllium poisoning. 

Llobet, J.M., J.L. Domingo, and J. Corbella. 1988b. Antidotes for zinc intoxication in mice. Arch. Toxicol. 61 321-323. 

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