Anticoagulant medicines

Due to bleeding risk, individuals on anticoagulant therapy or individuals who are vitamin K-deficient should not take vitamin E supplementation without close medical supervision. Absent of that, vitamin E is a well-tolerated relatively non-toxic nutrient. A tolerable upper intake level of 1,000 mg daily of a-tocopherol of any form (equivalent to 1,500 IU of RRR a-tocopherol or 1,100 IU of all-rac-a-tocopherol) would be, according to the Food and Nutrition Board of the Institute of Medicine, the highest dose unlikely to result in haemorrhage in almost all adults. 

Handin RI Anticoagulant, fibrinolytic and antiplatelet therapy. In Harrison s Principles of Internal Medicine, 15 th ed. Braun-wald E et al (editors). McGraw-Hill, 2001. 

Linkins, L. and Weitz, J. 2005. New anticoagulant therapy. Annual Review of Medicine 56, 63-77. 

Medical devices may be assisted in their function by pharmacological, immunological or metabolic means, but as soon as these means are not any more ancillary with respect to the principal purpose of a product, the product becomes a medicinal product. The claims made for a product, in accordance with its method of action may, in this context, represent an important factor for its classification as MD or medicinal product. Examples of MDs incorporating a medicinal substance with ancillary action include catheters coated with heparin or an antibiotic, bone cements containing antibiotic and blood bags containing anticoagulant. ... 

The oleosin fusion procedure was used for the purification of the commercially valuable plant-based blood anticoagulant hirudin in transgenic Brassica carinata and Brassica napus. Hirudin, a natural protein from the medicinal leech Hirudo medicinalis, is superior to other anticoagulants such as heparin. Recombinant hirudin was cleaved from oil-bodies using endoproteinase Factor Xa. Released hirudin was biologically active, as determined by a colorimetric thrombin inhibition assay. 

Be careful when using these herbs together with anticoagulants from western medicine. 

MNPs, which have been used as template to develop therapeutic drugs. MNPs isolated from invertebrates have shown wide range of therapeutic properties including antimicrobial, antioxidant, antihypertensive, anticoagulant, anticancer, anti-inflammatory, wound healing and immune modulator, and other medicinal effects.Therefore, marine invertebrates are rich sources of chemical diversity and health benefits for developing drug candidates, cosmetics, nutritional supplements, and molecular probes that can be supported to increase the healthy life span of human. 

Great amount of marine fish species have been identified with potential nutraceutical and medicinal values. Consequently, a number of bioactive compounds have been identified including fish muscle proteins, peptides, collagen and gelatin, fish oil, fish bone. Bioactive peptides derived from various fish muscle proteins have shown various biological activities including antihypertensive, antibacterial, anticoagulant, anti-inflammatory, and antioxidant activities, and hence they may be a potential material for biomedical and... 

In retrospect, it seems probable that the medical profession gained far more from Link s successes as an agricultural chemist than it could have from his practice of medicine. The discovery of Dicumarol and its adoption as an important clinical anticoagulant, and the synthesis of Warfarin and its development as a widely used rodenticide—these accomplishments, which will not be described in this article, alone were more than sufficient to make Karl Link an important name in science. For his work on Dicumarol, Link received the Cameron Award from the University of Edinburgh in 1952, the Lasker Award in 1955 and 1960, the John Scott Award in 1959, and the Kovalenko Medal of the National Academy of Sciences in 1967. He was a Harvey Lecturer... 

This compound is also of the coumarin family. The fonnula is 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin. In addition to use in anticoagulant therapy in medicine, the compound also has been used as a major ingredient in rodenhcides, where the objective is to induce bleeding and, when used in heavy doses, is thus lethal. The compound can be prepared by the condensation of benzylidene-acetone and 4-hydroxycoumann. 

The saliva of the medicinal leech contains a battery of substances that interfere with the hemostatic mechanisms of the host. One of these compounds is hirudin, a potent anticoagulant, which maintains the fluidity of the ingested blood and is the most potent inhibitor of thrombin. Upon binding to thrombin, the cleavage of fibrinogen and subsequent clot formation are prevented. The potency and specificity of hirudin make it a useful antithrombin-III-independent alternative to heparin for the control of thrombosis. 

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