Hormonal anticancer drugs

Since the theory and medical applications of collagen sponge were described by Chvapil et al. (52-54), they have been used to deliver steroid hormones (55), the anticancer drugs trans-retinoic acid (TRA) (56,57), and 5-fluorouracil (5-FU) (58), and antibiotics (59). 

Pt(TV) Prodrugs. Platinum(IV) complexes have been widely studied as potential prodrugs that avoid the limitations of the cisplatin class of anticancer drugs. Indeed, the Pt(IV) compound satraplatin [Pt(cha)Cl2(OAc)2(NH3)] (cha, cyclohexylamine) is currently in clinical trials for treatment of hormone-refractory prostate cancer (Fig. 1) (22). Satraplatin is the first orally bioavailable platinum derivative under active clinical investigation and is particularly attractive because of the convenience of administration, milder toxicity profile, and lack of cross-resistance with cisplatin. These results are promising and support the idea that platinum(IV) complexes offer the opportunity to overcome some of the problems associated with cisplatin and its analogs. 

ANTICANCER AND IMMUNOMODULATING DRUGS HORMONES AND HORMONE ANTAGONISTS Lanreotide... 

The anticancer drugs cisplatin cyclophosphamide - and ifosfamide alter the profile of P450 enzyme expression in liver and perhaps other tissues, at least in part due to the hormonal perturbations that these cytotoxic agents induce. Treatment of adult male rats with a single dose of cisplatin depletes serum androgen, and this effect persists for up to 28 days after drug administration . Serum androgen depletion by cisplatin is associated with a feminization of hepatic liver enzyme expression. Thus, cisplatin-treated male rats have elevated levels of the female-predominant... 

LeBlanc, G.A., S.S. Sundseth, G.F. Weber, and D.J. Waxman (1992). Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer Res. 52, 540-547. 

Anticancer drugs etoposide, doxorubicin, vincristine Ca + channel blockers dUtiazem, verapamil HIV protease inhibitors indinavir, ritonavir Antibiotics/antifungals erythromycin, ketoconazole Hormones testosterone, progesterone Immunosuppressants cyclosporine, FK506 (tacrolimus)... 

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