Antibodies carcinoembryonic

Antibody, scFv, against carcinoembryonic antigen Callus Oryza sativa (rice) Microparticle bombardment of callus Maize ubiquitin-1 Murine heavy-and light-chain IgG 0.45 jig g"1 fresh weight without KDEL (i) 3.8 jug g-1 fresh weight with KDEL (i) 31... 

Human carcinoembryonic antigen Mouse/human chimeric IgGl antibody (cT84.66) Antibody - mediated cancer therapy (colon cancer, breast cancer and tumor with epithelial origin) N. tabacum cv petit Havana SRI (Transient expression) 35S MSP + 1 mg/kg FLW 42... 

CEA-scan (Arcitumomab, murine monoclonal antibody (Mab) fragment (Fab), directed against human carcinoembryonic antigen, CEA)... 

MFE23 (Fv) TNF-a MFE23 contains Fv amino-acid sequences of antibody binding domain Binds to carcinoembryonic antigen (CEA) expressed on many cancer cells TNF-a Tumoricidal activity and associated inflammatory responses The F, domain of MFE23 antibody fragment increases the target selectivity of TNF in mice [107,108]... 

Arcitumomab is a murine F(ab )2 fragment from an anti-carcinoembryonic antigen (CEA) antibody labeled with technetium 99m... 

Pervin, S., Chakraborty, M., Bhattacharya-Chatteijee, M., Zeytin, H., Foon, K.A. and Chatterjee, S.K. (1997) Induction of antitumor immunity by an anti-idiotype antibody mimicking carcinoembryonic antigen. Cancer Res., 57, 728-734. 

In another Eu-Tb two-color immunoassay for two low concentration components, highly luminescent labels, BPTA-Tb3+ and BHHCT-Eu3+ were used for human serum AFP and CEA (carcinoembryonic antigen) by Yuan et al. (2001) (fig. 12). As shown in fig. 10, a well was coated with AFP and CEA antibodies, and after the serum sample was applied, anti-AFP antibody labeled with BHHCT-Eu3+ and anti-CEA antibody labeled with biotin were reacted. After washing the well and measuring the emission of the Eu chelate at 615 nm, SA labeled with BPTA-Tb3+ was added and the emission of the Tb chelate at 545 nm was measured. In this system, the detection limits of AFP and CEA were very low, 44 pg/ml and 76 pg/ml, respectively. 

C17. Constanza, M. E., Pinn, V., Schwartz, R. S., and Nathanson, L., Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome. N. Engl.. Med. 289, 520-523 (1973). 

Durbin H, Young S, Stewart LM, Wrba F, Rowan AJ, Snary D, et al. An epitope on carcinoembryonic antigen defined by the clinically relevant antibody PR1A3. Proc Natl Acad Sci USA 1994 91(10) 4313-4317. 

Blumenthal RD, Hansen HJ, Goldenberg DM. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res 2005 65 8809-17. 

Behr T, Becker W, Hannappel E, Goldenberg DM, Wolf F.Targeting of liver metas-tases of colorectal cancer with IgG,F(ab )2, and Fab anti-carcinoembryonic antigen antibodies labeled with 99mTc the role of metabolism and kinetics. Cancer Res 1995 55 5777s-85s. 

Fig. 37.—Antibodies directed at colon-tumor glycoprotein antigens. A Carcinoembryonic antigen on gel electrophoresis (I), gel embedded in agar (2). precipitin area (3), tumor antibody (4). B Tumor colon KC1HC1 extract (6), embedded gel (7), precipitin area (8), antibodies (9), extract of normal colon (5). C Agar diffusion of tumor-colon antibodies, C = carcinoembryonic antigen, E = new tumor colon antigens, S, = serum to C EA, S2 = serum to E x indicates periodate-oxidized antigens. [Data from J. H. Pazur, J. Chromatogr. B., 663 (1995) 51-57.)...

Use of Zirconyl Phosphate Gel for the Separation of Antigens from Antigen-Antibody Complexes in Radioimmunoassays Assays for Carcinoembryonic Antigen, a-Fetoprotein, and Insulin... 

Sheahan, K, O Brien, M J, Burke, B Dervan, P. A O Keane, J. C., Gottlieb, L. S., and Zamcheck, N (1990) Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies Am J. Clin Pathol. 94, 157-164... 

Mach, J.P. Carrel, S. Forni, M. Ritschard, J. Donath, A. Alberto, P. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma a critical evaluation. N. Eng. J. Med. 1980, 303, 5-20. 

Buchegger, F. Haskell, C.M. Schreyer, M. Scazziga, B.R. Randin, S. Carrel, S. Mach, J.-P. Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice. J. Exp. Med. 1983, 158, 413 27. 

Smoking affects the body s immune response. For example, serum IgA, IgG, and IgM levels are generally lower in smokers than in nonsmokers, whereas the IgE concentration is higher. Smokers, more often than nonsmokers, may show the presence of antinuclear antibodies and test weakly positive for carcinoembryonic antigen. The sperm count of male smokers is often reduced compared with that in non-smokers the number of abnormal forms is greater and sperm motility is less. 

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