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Antibiotic screening

An entire antibiotic screen can be carried out using 4 samples with the assay time being 15 min to 1 h depending upon whether the qualitative or quantitative mode is desired. [Pg.147]

The new approach expanded, rather than displaced, existing functional and technical capabilities. Screening—sometimes random, sometimes targeted—continued to be used and in many cases was less costly than discovery by design. In the continuing research for new antibiotics, screening remained the most effective approach to discovery, though both approaches were often employed. [Pg.181]

Other tests based on the use of swabs and microbial inhibition assays were developed at the US Department of Agriculture and Food Safety and are widely used in the United States of America and Canada primarily by meat inspection agencies, including the swab test on premises (STOP), calf antibiotic screen test (CAST), and the fast antibiotic screen test (FAST)." 45 -j g STOP assay employs Bacillus subtilis, and the CAST and FAST assays use Bacillus megaterium. However, these tests will not be discussed further in the context of commercially available assays. [Pg.160]

Past and many current antibiotic screening programs, no matter how sophisticated the screens, have utilized mostly empirical approaches that relied on the principle of serendipity for success. With a large enough sample size, a high enough throughput, and... [Pg.4]

Antiviral Antibiotics - Screening fermentation mixtures, identifying known compounds, and assaying samples during the purification of active fermentation products, are considered to be more difficult than the examination of pure synthetic compounds as antiviral agents. However, a review of the development of useful antibacterials would indicate that the increased effort is Justified. While most antibiotics isolated as antibacterial substances will eventually be tested in antiviral systems, it seems valid to expect certain cultures to produce specific antivirals which are not inhibitors of other microorganisms. In a series of papers on antiviral and antitumor antibiotics, Takatsuki have pre-... [Pg.106]

Keywords Antibiotics screening Enviromnental DNA Heterologous biosynthesis Synthetic biology Systematic engineering... [Pg.95]

A little over twenty years ago, in the late 1940 s and early 1950 s the authors were engaged in antibiotic screening and other microbiological research projects we remember well the introduction and development of the new analytical tool, paper chromatography. It was finding its place in the analysis of various biologically interesting substances such as alkaloids, steroids, vitamins, amino acids and finally antibiotics. [Pg.516]

Westley JW (1977) Polyether antibiotics versatile carboxylic acid ionophores produced by Streptomyces. Adv Appl Microbiol 22 177—223 Woodruff HB, McDaniel LE (1958) Antibiotic approach in strategy of chemotherapy. Soc Gen Microbiol Symp 8 29-48 Woodruff HB, Hernandez S, Stapley EO (1979) Evolution of antibiotic screening programme. Hindustan Antibiot Bull 21 71-84 Yu T, Shen Y, McDaniel R, Floss HG, Khosla C, Hopwood DA, Moore S (1998) Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases. J Am Chem Soc 120 7749-7759... [Pg.280]


See other pages where Antibiotic screening is mentioned: [Pg.35]    [Pg.218]    [Pg.509]    [Pg.84]    [Pg.66]    [Pg.13]    [Pg.1018]    [Pg.4]    [Pg.182]    [Pg.182]    [Pg.201]    [Pg.210]    [Pg.211]    [Pg.163]    [Pg.70]    [Pg.1]    [Pg.82]    [Pg.263]    [Pg.97]    [Pg.108]    [Pg.109]    [Pg.516]    [Pg.516]    [Pg.262]   
See also in sourсe #XX -- [ Pg.4 ]




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