Plasmids antibiotic resistance

Smith HW, Z Parsell, P Green (1978) Thermosensitive antibiotic resistance plasmids in enterobacteria. J Gen Microbiol 109 37-47. 

Preston-Mafham J, Boddy L, Randerson PF (2002) Analysis of microbial community functional diversity using sole-carbon-source utilisation profiles -a critique. FEMS Microbiol Ecol 42 1-14 Quentmeier A, Friedrich CG (1994) Transfer and expression of degradative and antibiotic resistance plasmids in acidophilic bacteria. Appl Environ Microbiol 60 973-978... 

Smalla K, Fleuer H, Gotz A, Niemeyer D, Krogerrecklenfort E, Tietze E (2000) Exogenous isolation of antibiotic resistance plasmids from piggery manure slurries reveals a high prevalence and diversity of IncQ-Like plasmids. Appl Environ Microbiol 66 4854-4862... 

Studies by Levine et al. (1983) have addressed the issue of plasmid mobilizations, the movement of plasmids between different host cells. Human volunteers fed tetracycline along with E. coli HS-4 (typical of the normal intestinal flora of humans) bearing highly mobilized plasmids (e.g., pJBK5) that carried resistance to chloramphenicol and tetracycline became co-colonized with E. coli HS-4 bearing the antibiotic-resistant plasmid. However, the use of a poorly mobilizable plasmid (pBR325) did not result in plasmid transfer. 

Tennstedt T, Szczepanowski R, Braun S et al (2003) Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a waste water treatment plant. EEMS Microbiol Ecol 45(3) 239-252... 

Schluter A, Szczepanowsld R, Puhler A et al (2007) Genomics of IncP-1 antibiotic resistance plasmids isolated from waste water treatment plants provides evidence for a widely accessible drug resistance gene pool. KEMS Microbiol Rev 31(4) 449-477... 

Naik, G. A., Bhat, L. N., Chopade, B. A. Lynch, J. M. (1994). Transfer of broad-host-range antibiotic resistance plasmids in soil microcosms. Current Microbiology, 28, 209-15. 

Timmis, K. N., Gonzalez-Carrero, M. I., Sekizaki, T. Rojo, F. (1986). Biological activities specified by antibiotic resistance plasmids. Journal of Antimicrobial Chemotherapy, 18 (Suppl. C), 1-12. 

Put selective pressure against plasmid-free cells using ctuxotrophic mutants or antibiotic-resistant plasmids (Parker and DiBiasio, 1987). Auxotrophic mutant is the cell which is mutated so that it requires a specific growth substance beyond the minimum required for normal metabolism and reproduction. 

Many of these enzymes are encoded in plasmids, small circular pieces of DNA often carried by bacteria. Many plasmids are readily transferred from one bacterial cell to another, transmitting the capability for antibiotic resistance. Plasmid transfer thus contributes to the spread of antibiotic resistance, a major health-care challenge. On the other hand, plasmids have been harnessed for use in recombinant DNA methods (p. 143). 

Bernhard, K., Schrempf, H., and Goebel, W. (1978) Bacteriocin and antibiotic resistance plasmids in... 

Eoegeding, P. M., Stanley, N. W. (1991). Listeria innocua transformed with an antibiotic resistance plasmid as a thermal resistance indicator for Listeria monocytogenes. Journal of Food Protection, 54, 519-523. 

Antibiotic Resistance Plasmids from Thermophilic Bacilli and Construction of Deletion Plasmids, J. Bacterlol., 146 1091 (1981). 

Resistance to the toxic effects of mercury is quite commonly found in bacteria (Silver and Walderhaug 1992 Misra 1992). Since most bacteria are rarely exposed to toxic levels of mercury, the resistance mechanism is inducible and is frequently found on plasmids and/or transposons. Many of the multi-antibiotic resistance plasmids that are frequently found in clinical collections have determinants of mercury resistance as well. Furthermore, mercury resistance is a consistent component of the chromosomal resistance determinant of MRS A (methicillin-resistant Staphylococcus aureus), a current clinical problem and one with no apparent connection to the use of mercurials. If the mercury resistance system is present, the expression of the detoxifying activities is tightly regulated and turned on only when needed. The MerR regulatory protein turns on mRNA synthesis by a positive activator mechanism (for primary references, see Silver and Walderhaug 1992 Misra 1992). 

Yu P-L, Pearce LE (1986) Conjugal transfer of streptococcal antibiotic resistance plasmids into Clostridium acetobutylicum. Biotechnol Lett... 

---