Resistance mechanisms antibiotics

Canton R (2009) Antibiotic resistance genes from the environment a perspective through newly identified antibiotic resistance mechanisms in the clinical setting. Clin Microbiol Infect 15(Suppl l) 20-25... 

The mar region has been cloned and sequenced this reveals an operon composed of three putative structural genes, marR, mar A and marB [211]. The mar regulon of E.coli is a unique antibiotic resistance mechanism in... 

Spontaneous mutation brings about organisms with novel antibiotic resistance mechanisms. If these cells are viable, in the presence of the antimicrobial agent selective multiplication of the resistant strain occurs so that it eventually dominates as above. 

Woodford, N. (2005) Biological counterstrike antibiotic resistance mechanisms of Gram-positive cocci. Clinical Microbiology and Infection,... 

Antimicrobial resistance is a growing threat worldwide, especially within hospitals harboring critically ill patients who are less able to fight off infections without the help of antibiotics. Resistance mechanisms have been found for every class of antibiotic agent and the search for new antibiotics effective against various multiresistant germs is probably one of the most difficult challenges of medicinal chemistry for the next decade. Development of new classes of antibiotics or more robust versions of old classes will be essential for the future. °... 

Hrabak J, Chudackova E, Walkova R. Matrix-assisted laser desorption ionization-time of flight (MALDI-TOL) mass spectrometry for detection of antibiotic resistance mechanisms from research to routine diagnosis. Clin Microbiol Rev. 2013 26 103-14. 

Vranakis I, Goniotakis I, Psaroulaki A, Sandalakis V, Tselentis Y, Gevaert K Tsiotis G. Proteome studies of bacterial antibiotic resistance mechanisms. J. Proteomics 2014 97 88-99. 

Overall, the shotgun-proteomics findings were consistent with the minimal inhibitory concentration (MIC) determination results because all 20 A. baumannii clinical isolates were foimd resistant to carbapenem, monobactam, cephalosporin, and to a combination treatment of penicillin and P-lactamase inhibitors. The results obtained demonstrate that by augmenting the custom DB with strain-specific unique peptide sequences, it is possible to obtain simultaneously both strain-level identification of. baumannii clinical isolates and their antibiotic resistance mechanism information within 5-6 h. Therefore, the approach developed by Chang et al (2013) could be used for a rapid, sensitive, and specific detection of P-lactam-resistant strains of. baumannii. 

Identification of Antibiotic Resistance Mechanisms in Bacteria Using Tryptic Peptides... 

The first antibiotic resistance mechanism described was that of penicillinase. Its presence and activity were first reported by Abraham and Chain in 1940 shortly after its discovery (Abraham and Chain 1940). 

Vega, N.M, and Gore, J. (2014) Collective antibiotic resistance mechanisms and implications. Curr. Opin. Microbiol, 21, 28-34,... 

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