Antiangiogenics

A comprehensive website summarizing the status of tumor antiangiogenic compounds in various stages of clinical trial is maintained by the National Cancer Institute at www.cancer.gov/clinicaltrials/developments/ anti-angio-table. Following is a survey of the most important substances currently in clinical development. [Pg.84]

Angiogenesis and Vascular Morphogenesis. Table 2 Antiangiogenic therapeutic strategies (noncomprehensive list)... [Pg.85]

Thalidomide Polycyclic teratogen, antiangiogenic mechanism unknown... [Pg.85]

Systematic screening experiments have identified more than 100 synthetic compounds with potent antiangiogenic activity. The mode of action for most of these molecules is not well understood, but some of the 40 compounds are well advanced in clinical trials (Table 3). The first substance to have entered clinical trials was the Fumagillin-derivative AGM 1470. Fumagillin is an antibiotic which inhibits bFGF- and PDGF-induced endothelial cell proliferation. The mechanism of action of AGM 1470 is poorly understood, but it was shown that it binds and inhibits the metalloprotease methionine aminopeptidase (MetAp-2). [Pg.87]

Reliable markers are needed to monitor the activity of antiangiogenic dtugs. Circulating endothelial cells and their progenitor subset are a potential candidate, as is MRI dynamic measurement of vascular permeability/ flow in response to angiogenesis inhibitors, but neither has been clinically validated. [Pg.1272]

FiggWD, Pluda JM, Sartor O (1999) In Teicher BA (ed), Antiangiogenic Agents in Cancer Therapy. Humana, Totowa, NJ, p. 371... [Pg.66]

Use antineoplastic, immunosuppressive, multiple sclerosis therapeutic, antiangiogenic, disease modifying drug, systemic lupus erythematosus therapeutic... [Pg.989]

R (2002) Novel antiangiogenic effects of the bisphosphonate compoimd zoledronic acid. J Pharmacol Exp Then 302 (3) 1055-61. [Pg.221]

Quinoline Analogs as Antiangiogenic Agents and Telomerase Inhibitors... [Pg.329]

Thalidomide as monotherapy or combination therapy is beneficial in the treatment of multiple myeloma. The precise mechanism of action of thalidomide is unknown, but its antimyeloma activity may be due to its antiangiogenic and... [Pg.1422]

Antiangiogenic A substance that prevents the formation of new blood vessels. [Pg.1560]

Ru iraw5-[RuCl4 (Me2SO)(Im)r Anticancer agent NAMI-A antiangiogenic ... [Pg.812]

A. R. Gagliardi, M. Kassack, A. Kremeyer, G. Muller, P. Nickel, and D. C. Collins. Antiangiogenic and antiproliferative activity of suramin analogues. Cancer Chemother. Pharmacol. 41 117-124 (1998). [Pg.613]

The C-terminal NCI domain, called type XV endostatin or restin, has antiangiogenic activity similar to endostatin, the NCI domain of type XVIII collagen (see below). ° ° The NCI domain has a trimerization domain, a hinge region that is more sensitive to proteolysis in type XVIII collagen, and the endostatin domain. Lack of type XV collagen in mice causes a skeletal myopathy and cardiovascular defects. ... [Pg.486]

Wan X, Shen N, Mendoza A, Khaima C, Helman LJ. (2006) CCI-779 Inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism... [Pg.142]

Del Bufalo D, Ciuffreda L, TriscinogUo D, Desideri M, Cognetti F, Zupi G Milella M. (2006) Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirohmus. Cancer Res 66 5549-5554. [Pg.143]

Jung M, Tak J, Chung WY, Park KK. (2006) Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane. Bioorg Med Chem Lett 16 1227-1230. [Pg.333]

J. J. (2006) CRA-026440 a potent, broad-spectrum, hydroxamic histone deacetylase inhibitor with antiproliferative and antiangiogenic activity in vitro and in vivo. Molecular Cancer Therapeutics, 5, 1693-1701. [Pg.135]

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