Antiangiogenic Assays

Shi et al. reported on the synthesis and antiangiogenic activities of lino-mide and its analogs (compounds 11-16) [32], Three of the analogs are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the chicken chorioallantoic membrane (CAM) [41,42] angiogenesis assay. These compounds possessed considerable antiproliferative activities against isolated human umbilical vein endothelial (HUVEC) cells along with with no... 

VFL is a novel vinca alkaloid obtained by semisynthesis using super-acidic chemistry to introduce two fluorine atoms selectively at the 20 position of VRLB. The preclinical evaluations of the new derivative VFL have already suggested that certain in vitro assays, in addition to in vivo experiments, could be proposed to select more rationally newer generation Vincas. Moreover, recent studies have demonstrated that certain newly identifled properties, such as antiangiogenic activities, could enlarge the therapeutic usage of natural and semisynthetic vinca alkaloids. VFL is presently in phase III experimentation for treatment of bladder cancer and nonsmall-cell lung cancer (NSCLC) [72]. 

Using an in vitro SVR assay, Robinson et al. have demonstrated potent antiangiogenic properties in aromatic enone and dienone analogs of curcnmin, Based on a simple pharmacophore model, the aromatic enone and aromatic dienone analogs of curcumin were prepared nsing standard dmg design concepts. 

Several evidences demonstrated that evodiamine possesses in vitro and in vivo anticancer properties, such as antiproliferative, anti-metastatic, apoptosis-inducing, and antiangiogenic activities [82]. Evodiamine was able directly to reduce HUVEC capillary tube formation and invasion, using Matrigel assay. In vivo assay, using... 

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