Anti-proliferation effect

III. In vitro biological activity specificity and efficiency Cell culture Demonstrate specific antisense effect by various bioassays such as anti-viral and anti-proliferation effect, induction of apoptosis... 

Chen, J.K., and T.T. Chen. 2004. Chinese medical herbology and pharmacology. City of Industry, C A Art of Medicine Press. Cherdshewasart, W., W. Cheewasopit, and P. Picha. 2004. The differential anti-proliferation effect of white (Pueraria miri-fica), red (Butea superba), and black (Mucuna collettii) kwao krua plants on the growth of MCF-7 cells. /. Ethnopharmacol. 93(2-3) 255-260. 

The thalidomide analogs CPS49 (30) and CPS11 (31) have been reported to inhibit PI3/AKT signaling in multiple myeloma cells via an anti-angiogenic effect. These compounds are devoid of the teratogenic properties seen with thalidomide and are currently in preclinical development [66]. Compound 30, and to a lesser extent 31, induced a dose-dependent inhibition of proliferation in several multiple myeloma cell lines and reduced phospho-AKT levels [66]. These compounds also inhibited DNA synthesis in cell lines resistant to conventionally used anti-multiple myeloma drugs (e.g. dexamethasone, anthracyclines and melphalan) in a dose-dependent manner. 

This chapter describes the metabohsm of sphingosine and SIP, evidence to support their pro- and anti-apoptotic effects and their proposed sites of action on signaling processes that contribute to apoptosis and proliferation. 

Almost 20 years ago the ammonium tellnrolate AS 101 was demonstrated to possess immnnomodnlating properties and to mediate anti-tumour effects in rats. The same com-ponnd stimnlates hnman lymphoid cells to proliferate and produce lymphokines, tumour necrosis factor (TNF) and other cytokines in vitro ... 

These novel tetrameric bromotyrosine metabolites display a range of biological activities, including effects on calcium channels (1900), lipoxygenase inhibition (1772), tumor angiogenesis inhibition (1901), and endothelial cell anti-proliferation (1902). Syntheses of several bastadins have been accomplished (1903,1904). 

Antimony—metal complexes, characteristics, 2, 34 Anti-proliferation drugs, for parasites, 12, 458 159 Anti-tumor effects, Ti(IV) complexes, 4, 662 (—)-Antofine, via ring-closing diene metathesis, 11, 222 (t-)-Aphanomol 1, via [5+2]-cycloadditions, 10, 613-614 Apical ligands, iron complexes with, 6, 313 Aqua ligands... 

Aspirin, now commonly used for prevention of CHD and colon cancer, combined with butyrate exerted stronger anti-proliferate and pro-apoptotic effects than either alone. 

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