Anti-polio virus activity

Later was reported that variabilin (7a) is a good inhibitor of human secretory and cytosolic PLA2 with anti-inflammatory activity [32] and shows in vitro antiviral activity against Herpes simplex (HSV) and Polio vaccine (PV1) viruses [33]. The high cytotoxicity against the BSC cell line exhibited by variabilin severely limits its potential usefulness as antiviral agent [33]. 

A were effective against herpes simplex virus-1 (HSV-land 11) [82, 83]. Eudistomin K sulfoxide and eudistomin K have high activities against polio vaccine type-1 virus. Platinum (If) and palladium (11) complexes of harmaline, harmalol, harmine, and harman and ( )-Debromoeudistomin K were also observed to exhibit antiviral activities against influenza virus (A and B) and herpes virus [84]. Recently, harman and its derivatives were found to possess anti-HIV activities against human peripheral blood mmuHiuclear (PBM) cells [85]. 

Isoprlnoslne (NPT-10381) - It is proposed that the anti-influenza activity of isoprlnoslne (the p-acetamidobenzoate salt of the 1 3 complex of inosine and dlmethylaminolsopropanol) is due to an alteration of ribosomes such that they are more selective for host mRNA and less selective for viral mRNA. Isoprlnoslne administered to mice 24 hours after infection with influenza virus provided protection against mortality s and with sub-lethal virus innocula it decreased the respiratory morbidity. In experiments79 with herpes, vaccinia, polio and echovirus there was no reduction in cytopathic effect but there was a reduction in virus yield. 

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