Anti-influenza activity

Kim CU, Lew W, Wilhams MA, Liu H, Zhang L, Swaminathan S, Bischofberger N, Chen MS, Mendel DB, Tai CY, Laver WG, Stevens RC (1997) Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J Am Chem Soc 119 681-690... 

Shie J-J, Fang J-M, Wang S-Y, Tsai K-C, Cheng Y-SE, Yang A-S, Hsiao S-C, Su C-Y, Wong C-H (2007) Synthesis of Tamiflu and its phosphonate congeners possessing potent anti-influenza activity. J Am Chem Soc 129 11892-11893... 

The Pursuit of Potent Anti-influenza Activity from the Antarctic Red Marine Alga Gigartina skottsbergii... 

MFPC Grinization possesses marked anti-influenza activity which is demonstrated by considerable inhibition of viral reproduction, decreasing of mortality and reduction in intensity of inflammatory changes in the... 

Hayden FG, Rollins BS, Madren LK. Anti-influenza activity of the neuraminidase inhibitor 4-guanidino-Neu5Ac2en in cell culture and in human respiratory epithelium. Antiviral Res 1994 25 123-131. 

Reports on the anti-influenza virus effects of extracts from marine algae from all over the world have been found in the literature [115]. These results show that the blue-green algae (cyanobacterium) are able to produce compounds with anti-influenza activity that may be of potential clinical interest. For example, aqueous and methanolic extracts of cultured cyanobacteria of several genera. Microcystis, Nodularia, Oscillatoria, Scytonema, Lyngbya and Calothrix were evaluated for their in vitro antiviral activity against the influenza A virus in Madin Darby kidney cells [116,117]. The further analysis of methanolic extracts of cultured strains of genus Microcystis revealed a remarkable antiviral... 

Two other monocyclic amine types (XXI, XXII) have been claimed to have anti-influenza activity but no details are available [94,95]. 

In Chapter 7, Bekhit and Bekhit discuss the various natural compounds/ extracts that have exhibited in vitro and in vivo antiviral activities with emphasis on anti-influenza activity. 

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