Anti-platelet aggregation

Barriault developed a new pericyclic domino process for the synthesis of the bioactive diterpenoid vinigrol (4-262), which was isolated from Vtrgaria nigra [92]. The natural product possesses antihypertensive and anti-platelet-aggregating properties. 4-262 contains a unique tricyclo [4.4.4.04a8a]tetradecane framework, which could be obtained by a combination of an oxy-Cope, a Claisen and an ene reaction... 

Igawa T Tani T Chijiwa T, et al. Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. Thromb Res 1990 57 617-623. 

Anti-Platelet aggregation inhibitor Veterinary drug Schizophrenia... 

Tsai, I. L. Wun, M. F. Teng, C. M. Ishikawa, T. Chen, I. S. Anti-platelet aggregation constituents from Formosan Toddalia asiatica. Phytochem., 1998, 48 1377-1382. 

Anti-platelet aggregation and anti-thrombosis Butylidenephthalide (20), 3/ -Butylphthalide (31), 3S-Butylphthalide (32), Z-Ligustilide (49), Senkyunolide A (58)... 

Ticlopidine (Figure 7.3), another substituted thiophene that is clinically utilized as an anti-platelet aggregation agent, is reportedly the first selective mechanism-based inactivator of CYP2C19 . This inactivation apparently occurs during S-oxidation of the thiophene moiety. The failure of GSH (5 mM) to inhibit ticlopidine-mediated... 

Yao K, Zhao M, Zhang X, Wang Y, Li L, Zheng M, Peng S (2011) A class of oral N-[(lS,3S)-l-methyl-l,2,3,4-tetrahydro-b-carboline-3-carbonyl]- NO-(amino-acid-acyl) hydrazine Discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. Eur J Med Chem 46 3237-3249... 

For decades, research on the health-promoting effects of Mediterranean diet has revealed that olive oil consumption is a key factor in the cardiovascular protection found in Mediterranean countries [139]. It is well established that the healthful properties of olive oil depend mostly on its high oleic acid content. However, many arguments demonstrate that in olive oil there are minor bioactive components, other than oleic acid, responsible for its cardiovascular protective properties among them, the phenolic fraction of olive oil, and in particular OL and HT, has demonstrated antioxidant, anti-platelet aggregation, vasodilatatory, and anti-inflammatory effects, all involved in this health beneficial action [7,108-110]. 

The anti-platelet aggregation approach to therapy attempts to prevent the formation of the platelet nidus and is thus a prophylactic type of therapy. 

Kodaira H, Ishikawa M, Komoda Y, Nakajima T 1983 Isolation and identification of anti-platelet aggregation principles from the bark of Fraxinus japonica Blume. Chem Pharm Bull 31 2262-2268... 

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