Anti-malarial drugs, synthetic

It will be interesting to see how much of this activity will survive in post-war conditions, especially in competition with new, synthetic, anti-malarial drugs developed during the war and revival of the Java cinchona industry, which is apparently making progress. 

As a practical result there are now at least six synthetic anti-malarial drugs available to malariologists, including the three pre-war drugs, pamaquln, mepacrine and plasmocide. 

Organic synthesis followed a different line of evolution. A landmark was Perkin s serendipitous synthesis of mauveine (aniline purple) in 1856 [26] which marked the advent of the synthetic dyestuffs industry, based on coal tar as the raw material. The present day fine chemicals and pharmaceutical industries evolved largely as spin-offs of this activity. Coincidentally, Perkin was trying to synthesise the anti-malarial drug, quinine, by oxidation of a coal tar-based raw material, allyl toluidine, using stoichiometric amounts of potassium dichromate. Fine chemicals and pharmaceuticals have remained primarily the domain of... 

Natural and synthetic O- and TV-heterocycles as new anti-malarial drugs 03AG(E)5274. 

Malaria, particularly drug-resistant malaria, is increasing rapidly again, shortly after the discontinuance of the aerial spraying of insecticides for harmful insects, including mosquitos, in consideration of the environment. Other than quinine, a number of synthetic drugs, such as chloroquine and mefloquine, as well as artemisinin, a peroxy-sesquiterpenoid isolated from Artemesia annua (Asteraceae), are used for malaria treatment. However, quinine still occupies an important position as an anti-malarial drug and is also present in drinks known as tonic water. ... 

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