Anti-adhesive drugs

Sharon, N., and Ofek, I. (2000). Safe as mother s milk Carbohydrates as future anti-adhesion drugs for bacterial diseases. Glycocon. J. 17, 659-664. 

Further work with other pili as well as analysis of multi-pili responses of the studied systems is on its way. With this information on hand, a significantly improved understanding of adhesion by piliated bacteria can be gained. Based on this knowledge, the search for new targets for anti-adhesion drugs in bacteria which possibly could lead to new means to combat bacterial infections, including those from antibiotic resistant bacterial strains [20,54,55], can be initiated. 

Sharon N (2006) Carbohydrates as future anti-adhesion drugs for infectious diseases. Biochim Biophys Acta 1760 527-537... 

Intravascular Red Cell Aggregation and Its Counteraction by Anti Adhesive Drugs on Brain Tissue Oxygenation, 6th European Conference on Microcirculation, Aalborg, 1970, Karger, Basel, 1971. 

For many years Wang and his group (2d) have carried out extensive research on glycopolymers (e.g., glycosylated linear polymers or hydrogels). In their review article, they described some of the characteristics of these polymers, particularly their use as anti-adhesion drugs. 

E. V. Sokurenko and W. E. Thomas, Structural basis for mechanical force regulation of the adhesin FimH via finger trap-like P sheet twisting. Cell, 2010, 141, 645-655 (b) M. M. Sauer, R. P. Jakob, J. Eras, S. Baday, D. Eris, G. Navarra, S. Bemeche, B. Ernst, T. Maier and R. Glockshuber, Catch-bond mechanism of the bacterial adhesin FimH, Nat. Common., 2016, 7, 10738. N. Sharon, Carbohydrates as future anti-adhesion drugs for infectious diseases, Biochim. Biophys. Acta, 2006, 1760, 527-537. 

Kelly, C. G., and Younson, J. S. (2000). Anti-adhesive strategies in the prevention of infectious disease at mucosal surfaces. Expert. Opin. Investig. Drugs 9,1711-1712. 

The actions of non-steroidal anti-inflammatory drugs appear to be diverse. Phenylbutazone and sulfmpyrzone inhibited several effects of FMLP on PMNs increased adhesiveness, stimulation of the hexosemonophosphate shunt, lysosomal enzyme release, and formation of O These effects were explained by the ability of both phenylbutazone and sulfinpyrazone to inhibit binding of labelled FMLP to PMNs. Both were selective in that neither inhibited responses of PMNs to Csa and neither inhibited the stimulation of the hexose monophosphate shunt by latex or by opsonized Candida. The responses of PMNs to FMLP, including the release of O have also been inhibited by 5,8,11,14 eicosatetraynoic acid, an inhibitor of the metabolism of arachidonic acid h by indomethacin and by... 

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