Bacteria anti-adhesive drugs

Further work with other pili as well as analysis of multi-pili responses of the studied systems is on its way. With this information on hand, a significantly improved understanding of adhesion by piliated bacteria can be gained. Based on this knowledge, the search for new targets for anti-adhesion drugs in bacteria which possibly could lead to new means to combat bacterial infections, including those from antibiotic resistant bacterial strains [20,54,55], can be initiated. 

Surfactants are used to permeabilise or lyse the cells to recover the product. E. coli cells can be made permeable to facilitate extraction by biosurfactants (Singh et al., 2007). Biosurfactants can be used as reagents for membrane permeabilisation for proteins (Desai and Banat, 1997). Recently Bhadoriyaet al. (2013) described role ofbiosiufactants producing bacteria in development of pharmaceutical additives and its use in solubility enhancement of poorly soluble drugs. Antimicrobial activity and anti-adhesive properties of biosurfactants are also greatly used in pharmaceutical industries. 

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