Anorexigenic agents

Bever, K, Perry, P. Dexfenfluramine hydrochloride an anorexigenic agent. Am. J. Health Syst. Pharm. 54 2059, 1976. 

When it was first introduced, one of the most frequent uses of amfetamine was as an anorexigenic agent in the treatment of obesity. A number of anorectic... 

Malcolm AD, Mace PM, Outar KP, Pawan GL. Experimental evaluation of anorexigenic agents in man a pilot study. Proc Nutr Soc 1972 31(1) 12A-14A. 

No breakthroughs were evident in the field of anorexigenic agents during 1966. Research continued to be concentrated on drugs related in structure to amphetamine. 

Further reports on the effect of anorexigenic agents on other metabolic factors such as blood glucose, liver glycogen, oxygen consumption and plasma insulin appeared. Whether these effects are secondary or are directly involved in anorexigenic action has not been resolved. 

Non-Phenethylamlne Derivatives - The search continues for anorectic compounds not structurally related to phenethylamines. An isoindole derivative, 5-hydroxy-5-p-chloropheny1-2,3-dihydro-5H-Imidazo[2,1-a]-Isoindole, 42-548 (XIV) has been reported to have moderate anorexic effects in monkeys at doses below those producing significant CNS Stimulation.63 In obese male patients 42-548 was found to be an effective anorexigenic agent with no significant effects on sleep or mood. ... 

Obesity and weight control received considerable but unfavorable publicity In the lay press regarding the indiscriminate use of the so-called "rainbow pills" the use of such preparations has been criticized. Obesity, however, continues to be a problem of great concern in the United States and is considered to be a major health hazard.2 An assessment of how anorexigenic agents are best used and the important role they play in weight control has been made.3... 

Several new derivatives of methamphetamine have been reported to be effective anorexigenic agents. An alkyl derivative (iVb) is reported to have an anorexigenic effect almost completely dissociated from the cardiovascular activity of its precursor. 6 A N-furfuryl derivative (V) [furfenorex] is reported to be effective in man, / and is currently being marketed in France. Its pharmacology indicates it to have sympathomimetic effects in both rats and dogs. 

Recent studies with 2-amino-5 p8enyl-2-oxazoline (XI) [aminorex] have shown it to be an effective anorexigenic agent with no significant difference in the igcidgnce or degree of side effects observed with marketed agents. 

Methods for the detection, identification and estimation of sympathomimetic amines and their metabolites in human urine by GLC and TLC have been advanced. 5 6 The procedures of Beckett S lend themselves to the analysis of a wide variety of basic drugs and their metabolites. Several simple and reliable laboratory procedures have been employed to test the ability of anorexigenic or potentially anorexigenic agents to produce central stimulation in animals these results correlate well with clinical experience. 7... 

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