Annotations from Screening Data

Most of the in vitro assays are described with an additional protocol for the assessment of metabolites however, it is unclear whether genuine high-throughput 

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Annotations from Positive Screening Data 11.8.2.1 Gene Mutation Assays... 

A two-dimensional slice may be taken either parallel to one of the principal co-ordinate planes (X-Y, X-Z and Y-Z) selected from a menu, or in any arbitrary orientation defined on screen by the user. Once a slice through the data has been taken, and displayed on the screen, a number of tools are available to assist the operator with making measurements of indications. These tools allow measurement of distance between two points, calculation of 6dB or maximum amplitude length of a flaw, plotting of a 6dB contour, and textual aimotation of the view. Figure 11 shows 6dB sizing and annotation applied to a lack of fusion example. 

Information of our chemical and siRNA libraries is stored in a PostgreSQL database. We annotate our validated hits using a DatabaseReader and a Joiner node to obtain either chemical structures for chemical screens or GenelD for RNAi screens. KNIME has many tools for cheminformatics, can visualize the molecule structures, and has tools to retrieve data from external public databases via Web queries to further annotate hits, allowing clustering either by chemical substructures or GO terms. 

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