Angiogenesis in the Lung

Johns Hopkins Bloomberg School of Johns Hopkins Asthma and Allergy Center, Public Health, Baltimore, Maryland, USA 

Imaging Neovascularization after Pulmonary Artery Obstruction 371 

---

Walsh DA, Pearson CL Angiogenesis in the pathogenesis of inflammatory joint and lung diseases. Arthritis Res 2001 3 147-153. 

Keedy VL, Sandler AB. Inhibition of angiogenesis in the treatment of non-small cell lung cancer. Cancer Sci 2007 98 1825-1830. 

CCRl is abundantly expressed on immune cells, including monocytes, memory T cells, basophils, dendritic cells [1-3, 22] and is induced by GM-CSF in neutrophils [23]. CCRl expression has been observed in airway smooth muscle cells in the lung suggesting a possible role in asthma [24], in both normal neurons [25] and in dystrophic neurons from patients with Alzheimer s dementia [26], in astrocytes [27], which suggests a role in inflammation in the CNS, in endothelial cells which can be induced to chemotax in response to CCL23 and may play a role in angiogenesis [28] and in multiple myeloma cells and osteoclasts [29, 30], hinting at a role for CCRl in bone cancer. 

---