Imaging neovascularization

III. Imaging Neovascularization after Pulmonary Artery Obstruction 371... 

The only modality which is in daily and widespread routine cHnical practice so far is the imaging of ocular diseases in ophthalmology. Fluorescein and ICG are established as fluorescent agents to enhance visuaHzation of chorioretinal diseases, such as vascular disorders, rethinopathies, neovascularization (age-related macular degeneration) or tumours [130,134,135]. 

Fig. 5.2. Retinal cross-sections of P17 mice exposed to hyperoxia in the ROP protocol. Significant numbers of neovascular tufts are apparent on the vitreal side of the ILM in untreated mice (top image). Two large vessels protruding beyond the ILM are indicated by arrows in the untreated eye. Many fewer such nuclei were observed in vector treated eyes (bottom image).

Proia, A., Chandler, D., Haynes, W., Smith, C., Suvamamani, C., Erkel, F., Klintworth, G. (1988). Quantitation of comeal neovascularization using computerized image analysis. Lab Invest. 58(4) 473-9. 

Rosenfeld PJ, Moshfeghi AA, PuMafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2005 36 331. 

Figure 4 Fluorescein angiography and LTA of an occult CNV in a rat model. The conventional fluorescein angiograms, obtained at (A) 29 sec and (B) 3.5min after injection, reveal the presence of a patchy fluorescent area that does not evolve over time and that provides no indication of CNV. In contrast, LTA (after release in the area marked by the circle) reveals a CNV with its exact location. (C, D, E) A brightly fluorescent abnormal pattern of vessels (CNV) (arrowhead) and fluorescent patches (arrows) (obtained 50,110 and 430 msec, respectively, after the end of dye release). These patches evolve rapidly into a lobular pattern characteristic of chorioca-pillaris. (F) The fluorescent bolus clears from the normal choriocapillaris while remaining in the CNV (image obtained after 1.2 sec). Abbreviations LTA, laser-targeted angiography CNV, choroidal neovascularization. Source From Ref. 16, Figure 3.

Baur A, Bartl R, Pellengahr C, Baltin V, Reiser MF (2004) Neovascularization of bone marrow in patients with diffuse multiple myeloma a correlative study of MR-imaging and histopathologic findings. Cancer 101 2599-2604 Baur-Melnyk A, Buhmann S, Durr HR, Reiser M (2005) Role of MRI for the diagnosis and prognosis of multiple myeloma. Eur J Radiol 55 56 64... 

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