Angiogenesis effects

Knighton, D., Silver, J. H. (1981). Regulation of wound-healing angiogenesis effect of Surgery, 90, 262—270. 

Pemg, C.-K., et al. In vivo angiogenesis effect of porous collagen scaffold with hyaluronic acid oligosaccharides. J. Surg. Res. 168(1), 9-15 (2011)... 

Since the recognition of at least two av integrin pathways for cytokine-mediated angiogenesis, av 33 and av 35 antagonists may be more effective in certain indications as compared to a specific anti- av 33. However, further work is needed to document this notion. 

Semaphorins are secreted, membrane-associated or transmembrane proteins defined by the presence of a sema-phorin protein domain (Serna domain). In the mammalian system, more than 20 semaphorins have been identified which play important roles in a variety of tissues. The best characterized receptors for mediating semaphoiin effects are members of the neuropilin and plexin families of transmembrane proteins. Semaphoiin functions are best described in the regulation of neural development, angiogenesis, immunoregulation and cancer. 

FIGURE 9 Influence of angiogenesis inhibitors on blood vessel growth. Several inhibitors of angiogenesis were released from PTA-SA 50 50 in vivo. The effect of these agents on the growth of blood vessels around the VX2 carcinoma implanted into rabbit corneas was then determined as described in the text. 

Data about curcunfin encapsulated in liposomes have been reported recently. The authors encapsulated curcumin into a liposomal delivery system in order to study the in vitro and in vivo effects of this compound on proliferation, apoptosis, signaling, and angiogenesis using human pancreatic carcinoma cells. Carotenoids of different polarities and in competition with cholesterol were specifically incorporated into liposomes in order to mimic the physiological uptake by cells and monitor their antioxidant capacities. ... 

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