Anemia, hemolytic sideroblastic

Different classifications of anemia are based in part on the pathophysiological factor inducing the decreased hemoglobin concentration. Anemias due to cell hy-poproliferation include aplastic anemia and iron deficiency anemia. Hemolytic anemia results from excessive destruction of red blood cells. Megaloblastic anemia, sideroblastic anemia, and iron deficiency anemia result from an abnormality in the maturation of red blood cells. 

Sideroblastic anemia j Aarskog-Scott syndrome PGK deficiency hemolytic anemia... 

Agranulocytosis, thrombocytopenia, hemolytic anemia, sideroblastic anemia (17), pure red cell aplasia (18), methemoglobinemia, and eosinophilia can occur exceptionally during isoniazid treatment (SEDA-9, 268) (19). An acquired coagulation factor XIII inhibitor developed in a patient taking isoniazid and resulted in a bleeding disorder (20). 

Sideroblastic anemia is characterized by the accumulation of iron in the mitochondria of erythroblasts. In a Phase I study in 35 patients with refractory tumors, eight taking CMT-3 developed anemia without leukopenia or thrombocytopenia (54). Three of these patients underwent bone-marrow examination and each had ringed side-roblasts. The authors referred to several cases of aplastic anemia, megaloblastic anemia, and hemolytic anemia in which members of the tetracycline family have been implicated. However, they stated that there has been no previous reports of sideroblastic anemia associated with any tetracycline derivative and that the molecular mechanisms by which CMT-3 might cause sideroblastic anemia are unclear. 

In iron deficiency anemia, zinc acts as an alternative substrate for FECH, leading to increased ZPP. Increased red cell protoporphyrin (mostly ZPP) may also occur in sideroblastic, megaloblastic, and hemolytic anemias. ... 

Sideroblastic anemia j Aarskog-Scott syndrome PGK drficiency hemolytic anemia Charcot-Marie-Tooth disease Choroideremia Cleft palate, X-linked Spastic paraplegia, X-linked, 2 Deafness with stapes fixation 1 PRPS-related gout... 

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