Androgen receptor blockers

The higher prevalence of tics in males and the exacerbating effects of anabolic steroids suggested the possibility that manipulation of steroid hormones might be helpful in the treatment of TS. Despite some promising case studies (Peterson et ah, 1994), however, a doubleblind, placebo-controlled, crossover study of the androgen receptor blocker flutamide, in 13 adults with TS, failed to find significant benefits (Peterson et al., 1998). 

Antiandrogens, or androgen-receptor blockers, should be avoided during pregnancy. Both cyproterone and spironolactone shonld be used for acne only in women, because they lead to feminization in men. ... 

Cyoctol, Hexahydro-4-(5-methoxyheptyl)-2(lH)-pentalenone 6-(5-methoxy-1 -heptyl)bicyclo[3.3,0]octan-3-one 2-(5-methoxyhept-l -yl)bicyclo[3.3.0]octan-7-one X-Andron CPC 10997 Exandron. CltHj,02 mol wt 252.40. C 76.14%, H 11.18%, O 12.68%. Topically active nonsteroidal androgen-receptor blocker. Prepn W. I. 

Flutamide androgen receptor blocker—used for androgen-receptor-positive prostate cancer... 

I Clinically useful drug antagonists are flutamide (an androgen-receptor blocker used to treat prostate i cancer), leuprolide (a GnRH analog used to treat prostate cancer), and finasteride (a 5-a-reductase I inhibitor used to treat benign prostatic hyperplasia and male pattern baldness). 

Pharmacology In vitro studies have shown inhibition of 5a-reductase and antagonistic effects at androgen receptors. Clinical trials of saw palmetto in benign prostatic hyperplasia (BPH) have shown improvement in urologic function and in urinary flow. When compared with finasteride in BPH, saw palmetto did not lower prostate-specific antigen or dihydrotestosterone levels. However, sexual dysfunction was less with saw palmetto than with finasteride. Clinical improvement of BPH with saw palmetto appears to be less than that with alpha-blockers. 

Finasteride and minoxidil are used to treat androgenic alopecia. Finasteride shrinks the prostate in benign prostatic hypertrophy (BPH). Flutamidc is a testosterone receptor blocker used in prostate... 

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