Androgen polymorphisms

Hormonal Does not occur in eunuchs. Low incidence in cirrhotic patients. Up to 80% are hormonally dependent. African-Americans have 15% increased testosterone. Japanese have decreased 5-a-reductase activities. Polymorphic expression of the androgen receptor. 

Bharaj B, Scorilas A, Diamandis EP, et al. Breast cancer prognostic significance of a single nucleotide polymorphism in the proximal androgen response element of the prostate specific antigen gene promoter. Breast Cancer Res Treat 2000 61 111-119. 

Lack of association of the 11 P-hydroxysteroid dehydrogenase type 53. 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen... 

It is common to find multiple solid forms of a single organic compound. For example, the androgen dehydroepiandrosterone (DHEA, Fig. 30) exists in at least seven solid forms. Three polymorphic forms, three hydrates, and a methanol solvate were made and characterized (40). Single-crystal structure determinations were carried out on forms I, SI, S3, and S4 (41,42). Structural features of the various forms are compared in Table 10 and Fig. 31. 

Wada, Y., Mitsumori, K., Terachi, T., and Ogawa, O. (1999) Measurement of polymorphic trinucleotide repeats in the androgen receptor gene by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom., 34 (8), 885-888. 

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