Ancylostoma caninum

ACAJ1593 Ancylostoma ceylanicum ACAJ 1591 Ancylostoma caninum... 

PDI isoforms have also been described in parasitic nematodes, including 0. volvulus (Wilson et al., 1994), Nippostrongylus brasiliensis (Tweedie et al., 1993), Ancylostoma caninum (Epe et al., 1998) and Dirofilaria immitis (Chandrashekar et al., 1998). However, their involvement in collagenfolding events in the respective organisms remains to be determined. 

Epe, C., Kohlmetz, C. and Schnieder, T. (1998) A recombinant protein disulfide isomerase homologue from Ancylostoma caninum. Parasitology Research 84, 763-766. 

A prominently expressed gene family in many parasitic nematodes bears similarity to allergens present in vespid (e.g. wasp) venom. For example, the canine hookworm Ancylostoma caninum expresses high levels of this protein when larvae are activated to invade (Hawdon et al., 1996). Similar genes are found in B. malayi (R.M. Maizels and J. Murray, 1999,... 

Burke, T.M. and Roberson, E.L. (1985) Prenatal and lactational transmission of Toxocara canis and Ancylostoma caninum experimental infection of the bitch before pregnancy. InternationalJournal for Parasitology 15, 71—75. 

Munn, E.A. and Greenwood, C.A. (1983) Endotube-brush border complexes dissected from the intestines of Haemonchus contortus and Ancylostoma caninum. Parasitology 87, 129-137. 

Grencis, R.K. and Cooper, E.S. (1996) Enterobius, Trichuris, Capillaria, and hookworm including Ancylostoma caninum. Gastroenterology Clinics of North America 25, 579-597. 

Considerably more is known about anticoagulants from the blood-feeding hookworm, Ancylostoma caninum. Several families of small, anti-clotting peptides have been described in A. caninum. AcAP, an 8.7 kDa peptide secreted by adult worms that does not exhibit homology to other anticoagulants, but is a potent inhibitor of Factor Xa, was described by Cappello et at. (1995). A family of related peptides, one of which uniquely inhibited a complex of blood coagulation factor VIIA and tissue factor, was also reported (Stanssens et al., 1996). 

Cappello, M., Vlasuk, G.P., Bergum, P.W., Huang, S. and Hotez, P.J. (1995) Ancylostoma caninum anticoagulant peptide a hookworm-derived inhibitor of human coagulation factor Xa. Proceedings of the National Academy of Sciences USA 92, 6152-61 56. 

Del Valle, A., Jones, B.F., Harrison, L.M., Chadderdon, R.C. and Cappello, M. (2003) Isolation and molecular cloning of a secreted hookworm platelet inhibitor from adult Ancylostoma caninum. Molecular and Biochemical Parasitology 129, 157-1 77. 

Zhan, B., Liu, Y., Badamchian, M., Williamson, A., Feng, J., Loukas, A., Hawdon, J.M. and Hotez, P.J. (2003) Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum. International Journal for Parasitology 33, 897-907. 

Creeping eruption or larva migrans in man is caused by the presence of the larvae of dog and cat hookworms, Ancylostoma caninum and A. braziliense in the skin. Some other nematodes like Uncimria stenocephala (European dog hookworm) and Gnathostoma spitiigerum also produce somewhat similar cutaneous lesions. The creeping eruption is prevalent in different regions of the warm climates, especially in the Americas, Africa and Asia. It is estimated that nearly 10 million people around the world suffer from this disease [24]. 

Creeping eruption Ancylostoma caninum, A. braziliensis, Gnathos-toma spinigerum Thiabendazole, mebendazole... 

Nitroscanate exhibits 99.6-99.8% activity against the hookworm, Ancylostoma caninum in dogs at a single oral dose of 50 mg/kg. However, it has no action against Trichuris vulpis [62,64]. 

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