Analysis Perspectives

The role of analytical technologies traditionally has been to respond to a pharmaceutical event, rather than to lead one. A complementary perspective from an analytical point of view can provide substantial insight into relevant drug development issues. This insight may not be intuitively obvious from a sample-generating (i.e., chemistry, biology) approach. And, when sample analysis activities are taken into consideration as an equal partner with sample-generating 

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The analysis of accidents and disasters in real systems makes it clear that it is not sufficient to consider error and its effects purely from the perspective of individual human failures. Major accidents are almost always the result of multiple errors or combinations of single errors with preexisting vulnerable conditions (Wagenaar et al., 1990). Another perspective from which to define errors is in terms of when in the system life cycle they occur. In the following discussion of the definitions of human error, the initial focus will be from the engineering and the accident analysis perspective. More detailed consideration of the definitions of error will be deferred to later sections in this chapter where the various error models will be described in detail (see Sections 5 and 6). 

Shonnard, D.R., Kicherer, A., Saling, P. (2003) Industrial Applications Using BASF Eco-Efficiency Analysis Perspectives on Green Engineering Principles. Environmental Science and Technology, 37, 5340-5348. 

Mechanistic analysis, perspectives in modem voltammetry basic concepts and, 32, 1... 

Brown, R.D. Descriptors for diversity analysis. Perspect. Drug. Disc. Des. 1997, 7/8, 31-49. 

M. Halkes, . H. Gotfredsen, M. Grotli, L. P. Miranda, J. O. Duus and M. Meldal, Solid-phase glycosylation of peptide templates and on-bead MAS-NMR analysis Perspectives for glycopeptide libraries, Chemistry-A European Journal, 2001, 7, 3584-3591. 

Mechanisms, of proton transfer between oxygen and nitrogen acids and bases in aqueous solutions, 22, 113 Mechanisms, organic reaction, isotopes and, 2, 1 Mechanisms of reaction, in solution, entropies of activation and, 1, 1 Mechanisms of reaction, of /3-lactam antibiotics, 23, 165 Mechanisms of solvolytic reactions, medium effects on the rates and, 14, 10 Mechanistic analysis, perspectives in modern voltammeter basic concepts and, 32, 1 Mechanistic applications of the reactivity-selectivity principle, 14, 69 Mechanistic studies, heat capacities of activation and their use, 5, 121 Mechanistic studies on enzyme-catalyzed phosphoryl transfer, 40, 49 Medium effects on the rates and mechanisms of solvolytic reactions, 14, 1 Meisenheimer complexes, 7, 211... 

A.O. Scott, Biosensors for food analysis perspectives. In A.O. Scott (Ed.), Biosensors for Food Analysis, The Royal Society of Chemistry, London, 1998, pp. 181-195. 

The third element is information. The rate of analysis and subsequent distribution of results has grown tremendously due to the increased use of LC/MS and other information-rich technologies. From strictly an analysis perspective, LC/MS has demonstrated a... 

Fell, D. A. (1998). Increasing the flux in metabolic pathways A metabolic control analysis perspective. Biotechnol Bioeng, 58(2-3), 121-124. 

Shonnard, D. R., Kichere, A., and Saling, P., industrial applications using BASF eco-efficiency analysis Perspectives on green engineering principles, Environ. Sci. Technol., 37, 5340-5348, 2003. 

Warr, W.A. Commercial Software Systems for Diversity Analysis. Perspect. DrugDisc. Des., 1997,7/8, 115-130. 

Spakovsky, M., Olsommer, B. (2002). Fuel cell systems and system modeling and analysis perspectives for fuel cell development. Energy Conversion Management 43,1249-1257. 

The final route, which has ultimately become the manufacturing process for aprepitant, utilized many of the same concepts as the previously discussed routes, but there was a significant strategic difference. The novel aspect of the plan, from a retrosynthetic analysis perspective, was that the stereocontrol element was chiral alcohol 37 and not one of the two stereocenters contained in the morpholine backbone The strategic themes that were conserved from some of the other routes included an acetalization and resolution at an epimerizable center. ... 

Roth, P. M., Blanchard, C. E., and Reynolds, S. D. (1989) The Role of Grid-Based Reactive Air Quality Modeling in Policy Analysis Perspectives and Implications as Drawn from a Case Study, EPA/600/3-89-082. U.S. Environmental Protection Agency, Research Triangle Park, N.C. 

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