Amyloid proteins self-aggregation

As a basis of various pathologic conditions, about 40 or more different proteins each can self-aggregate to form the "primary protein" of an amyloid. For example, in amyloid peripheral neuropathies the deposited extracellular amyloid often contains (a) the variable portion of immunoglobulin light chain in some B-lymphocyte dyscrasias, or (b) mutant transthyretin in some autosomal dominant hereditary amyloid neuropathies. 

Another hallmark of amyloid proteins is their capability to self-aggregate into insoluble fibrils with extensive p structures. This capacity further increases the complexity of the problem we are facing, because it adds a new type of structure to proteins already characterized by... 

Amyloid protein A protein that self-aggregates into organized fibrillar structures one of the main components of amyloid plaques. 

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