Amprolium hydrochloride

Amprolium Hydrochloride, C14H19CINH4HCI is of low molecular weight, 315.25 daltons. It is a white, odourless substance, readily soluble in water. It is a thiamine antagonist and is used in poultry feeds to prevent coccidioidomycosis. 

Allergic sensitivity to it was first reported by Feinberg and Watrous (1945), who elicited positive reactions to scratch tests in sensitised pharmaceutical workers. Rhinitis and asthma in subjects exposed to it as a sterilising agent is reported by Bourne et al. (1979). They elicited positive type I reactions to skin prick tests with unconjugated materials. 

The possible role, in allergenic potency for eliciting reactions, of the leaving chlorine ligands needs to be examined here, as has been done with the halide complex platinum salts (see Sect. B.I) and as also seems indicated for amprolium hydrochloride (see Sect. C.I). 

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Acetylcholine Chloride Ambenonium Chloride Amprolium Hydrochloride Atropine Methonitrate Bethanechol Chloride Bibenzonium Bromide Buformin Cadaverine Cetrimide... 

Greene SA, Freedman S (1976) Asthma due to inhaled chemical agents - amprolium hydrochloride. Clin Allergy 6 105-108... 

Amprolium hydrochloride Azadirachtin + camphor + curcumin (1 1 1) Azamethiphos (e.g. Salmosan) ... 

Pesticides. The compound 2-picoline is a component of l-[(4 -amino-2/- f-propyl-5 -pyrimidinyl )methyl]-2-picolinium chloride hydrochloride, known as Amprolium, a broad-spectrum coccidiostat. A newer coccidiostat is 3,5-dichloro-4-hvdToxy-2,6-lnfidine and known... 

The poultry industry employs the sulfonamides sulfaquinoxaline (114), also known as Diamprim, and sulfadimidine (115) for treatment of coccidiosis. The antimalarial pyrimethamine (116) (see Chapter 1) exhibits anti-coccidial properties, as does amprolium, APL, l-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride hydrochloride (116a), a thiamine antagonist73. 

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