Amphetamines precursors

Suffice to say that anything that remotely smells like sassafras oil or licorice or any of those strong rustic spices is going to have some amphetamine precursor, maybe not safrole exactly, but definitely something. There is just no other substitute in nature for the aroma these unique compounds give. 

You people won t believe the potential amphetamine precursors just sitting around in naturally occurring oils and essential oils [6, 7... 

Amphetamine/methamphetamine precursor (P2P seized in USA) ] Amphetamine precursors (P2P, phenylacetic acid, norephedrine) I Methamphetamine precursors (pseudo-ephedrine, ephedrine) Trend... 

Seizures of amphetamine precursor parallel the pattern mentioned above. Over the 2004-05 period most amphetamine precursor seizures (P-2-P) took place in the Netherlands (6,620 litres) and Poland (4,996 litres). The next largest seizures were reported by Germany (1,310 litres). Smaller quantities have been reported from Estonia (27 litres), Ireland (26 litres), Lithuania (24 litres), Belarus (18 litres) and Bulgaria (16 litres). If the period under investigation is extended, important P-2-P seizures were also reported from Belgium (4000 litres in 2001) and the UK (120 litres in 2002). Over the last five years the Netherlands reported the largest P-2-P seizures in Europe annually but these seizures have been falling (from 18,238 litres in 2001 to 340 in 2005). 

An identification problem arises in the analysis of khat in that catiunone will begin to degrade to cathine as soon as the khat b harvested. The analytical window b about two da) from that time. In addition, the electron impact mass spectrum of cathine b identical to that of phenylpropanolamine, an amphetamine precursor. 

Strike can t believe Strike can actually quote Strike s own book. That is so freaky )]. Most of these things will make amphetamines that are much more potent than X. It is also possible to play around with some of the little side groups on these to eventually make X or some other interesting psychotomimetics. With few exceptions these precursors are all substituted allylbenzenes just like safrole. They are all found in the same kind of legal oils and sold in the same kinds of places as sassafras. Finally, these precursors are turned into their own respective amphetamines using the exact same conversion recipes used for safrole. 

So let s say, for instance, that some deranged lunatic did the exact opposite of what this book says, and went ahead and got some equipment, a couple of chemicals and some safrole, isosafrole and/or the precursor of their choice. They may very well decide to do something to it to get it farther along the path to final product. Well, currently on the place called Earth, the most widely made precursor for X and amphetamine production is the phenylace-tone. For crystal meth the precursor is called just that phen-ylacetone (a.k.a. phenyl-2-propanone, a.k.a. P2P). For X the precursor would be called 3,4-Methylenedioxyphenylacetone (a.k.a 3,4-Methylenedioxy-phenyl-2-propanone, a.k.a. MD-P2P). Strike knows it should technically be written as MDP-2-P, but Strike has always written it incorrectly as MD-P2P and that is just how stupid-ass Strike is always gonna refer to it. 

This really crazy looking method is one of them. There are a lot of things about it that make it very attractive. The first is the author of the article Rajender S. Varma. You will see in the Nitropropene section of this book (and in references from many other parts of the book) that this guy has been making a lot of strangely applicable advances in catalysis, amination, and reduction of amphetamines and related compounds. It is uncanny how often Strike has come across this person s work. It is like he is the Shulgin of basic precursor and amphetamine progress. Go figure ... 

But we have many reasons. That is why the ground are actually progressing the fields of amphetamine science. Believe it or not, the Journal methods on precursors such as ours published research work. Half of the stuff in able, proper science done by people with no amazing when you think about it. 

Dyn is not yet known, it is likely that such changes reflect variations in the activity of the associated pathways. One possible explanation is that increases in neuropeptide tissue levels are due to decreased release of the transmitter, which dunmishes the extracellular peptide metabolism and results in accumulation of these peptide substances. Another possible contributing factor is a drug-related alteration in neuropeptide synthesis. For example, Bannon et al. (1987) reported that METH administration increased the quantity of striatal messenger RNA for the SP precursor preprotachykinin. Thus, increases in peptide synthesis might contribute to increases in peptide content caused by treatment with METH or the other amphetamine analogs. 

The root of the plant Acorus calamus (also called flag root and sweet calomel), which grows over much of the world, is chewed by the Cree Indians of Canada to produce psychedelic effects. The active compound seems to be asarone — a precursor in an hallucinogenic amphetamine. 

As early as the 1940s it became clear that amphetamine could also produce a calming effect in adults prone to aggression and agitation. Later, this so-called paradoxical effect was also seen in children with hyperkinetic syndrome, the precursor to ADHD. 

Predictable interactions occur between the MAOIs and any amine precursors, or directly or indirectly acting sympathomimetic amines (e.g. the amphetamines, phenylephrine and tyramine). Such interactions can cause pronounced hypertension and, in extreme cases, stroke. 

The competent authorities of the Netherlands, the task force member responsible for coordinating Project Prism activities in Europe, have launched a specific time-bound operation focusing on backtracking investigations. The operation is aimed at identifying companies and individuals responsible for the manufacture and diversion of precursors of amphetamine-type stimulants, specifically P-2-P, in the region. If successful, the operation may be expanded to include areas beyond Europe. 

Major manufacturing and trading countries now routinely supply pre-export notifications for all shipments of precursors of amphetamine-type stimulants in international trade. The Board has noted that, because of the effective controls and monitoring mechanisms that now exist for the licit trade in the raw materials, traffickers in certain regions are increasingly turning to pharmaceutical preparations as a source of the required precursors, particularly ephedrine and pseudoephedrine. 

Project Prism was launched at the International Meeting on Amphetamine-type Stimulant Precursors, which the Board convened in Washington, D.C., in June 2002. Operational activities commenced in January 2003. 

Operational activities have continued under Project Prism, the international initiative designed to address diversion of the five main precursors used in the illicit manufacture of amphetamine-type stimulants, namely, ephedrine, 3,4-methylene-dioxyphenyl-2-propanone (3,4-MDP-2-P), l-phenyl-2-propanone (P-2-P), pseudo-ephedrine and safrole, as well as the equipment used in such illicit manufacture. Activities during 2004 have focused on launching operations to address weaknesses in control and monitoring mechanisms identified during 2003, such as monitoring... 

---