Methotrexate Amiodarone

Isoniazid, methyldopa, amiodarone, methotrexate, phenothiazine, estrogen, anabolic steroids, black... 

Amiodarone, bleomycin, captopril, chlorpropamide, chlorpromazine, imipramine, methotrexate, and phenytoin... 

Drugs that may affect amiodarone include hydantoins, cholestyramine, fluoroquinolones, rifamycins, ritonavir, and cimetidine. Drugs that may be affected by amiodarone include anticoagulants, beta-blockers, calcium channel blockers, cyclosporine, dextromethorphan, digoxin, disopyramide, fentanyl, flecainide, hydantoins, lidocaine, methotrexate, procainamide, quinidine, and theophylline. Drug/Lab test interactions Amiodarone alters the results of thyroid function tests, causing an increase in serum T4 and serum reverse T3 levels and a decline in... 

Drugs that may affect cyclosporine include allopurinol, amiodarone, androgens (eg, danazol, methyltestosterone), anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), azole antifungals (eg, fluconazole, ketoconazole), beta-blockers, bosentan, bromocriptine, calcium channel blockers, colchicine, oral contraceptives, corticosteroids, fluoroquinolones (eg, ciprofloxacin), foscarnet, HMG-CoA reductase inhibitors, imipenem-cilastatin, macrolide antibiotics, methotrexate, metoclopramide, nafcillin, nefazodone, orlistat, potassium-sparing diuretics, probucol, rifamycins (rifampin, rifabutin), serotonin reuptake inhibitors (SSRIs eg, fluoxetine, sertraline),... 

Echinacea 1. Hepatotoxic drugs, e.g. anabolic steroids 2. amiodarone 3. Methotrexate 4. Ketoconazole Risk of additive hepatotoxicity Use of echinacea for over 8 weeks can cause hepatotoxicity Be aware and use drugs with a potential to cause hypertonicity cautiously, monitoring clinically and biochemically for any early signs of hepatic dysfunction... 

Hepatic fibrosis or cirrhosis may be caused by therapeutic use of methotrexate, e.g. for psoriasis in the latter case the risk is lessened by giving a large dose weekly rather than a smaller dose daily and by monitoring progress by liver biopsy after every 1.5-2 g of methotrexate. Chronic exposure to amiodarone may lead to cirrhosis this drug can also cause an alcoholic hepatitis-like picture. 

An isolated case report tentatively attributes the development of methotrexate toxicity with the concurrent use of amiodarone. 

An elderly woman, whose psoriasis was effectively controlled for 2 years with methotrexate, developed ulceration of the psoriatic plaques within 2 weeks of starting treatment with amiodarone. The reason is not understood. A modest increase in her dosage of furosemide is a suggested contributory factor because it might have interfered with the excretion of the methotrexate. ... 

Reynolds NJ, Jones SK, Crossley J, Harman RRM, Methotrexate induced skin necrosis a drug interaction with amiodarone BMJ (1989) 299, 980-1,... 

Dmg-indnced DPLD Selected medications nitrofurantoin, methotrexate, amiodarone, sulfasalazine, phenytoin, bleomydn, interferon-a, multiple chemotherapeutic agents, radiation Systemic diseases associated with DPLD Sarcoidosis Vasculitis Amyloidosis... 

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