3 - Aminopropyltriethoxysilane

These two selectors terminated with a glycine were then prepared on a larger scale, their carboxyl groups reacted with 3-aminopropyltriethoxysilane, and the conjugate immobilized onto silica. Each CSP was packed into columns and used for the separation of racemic (l-naphthyl)leucine ester 17. Separation factors of 6.9 and 8.0 were determined for the columns with DNB-ala-gly and DNB-leu-gly selector respectively. These were somewhat lower than those found for similar CSPs using the parallel synthesis and attached through a different tether [87]. 

Thus, the ring-opening polymerization of 2-methyl-2-oxazoline followed by the treatment of the resulting oxazolinium propagating end group with 3-aminopropyltriethoxysilane produced successfully triethoxysilyl-terminated poly-oxazoline as shown in Scheme 3 [29]. 

Anchored amine materials can be prepared through a number of synthetic methodologies. Because of the potential importance of these materials to organic synthesis, a ninhydrin assay was developed as a rapid laboratory determination of available surface amines. The assay agreed well with expected values for aminopropyltriethoxysilane grafted onto commercial silica. The assay also distinguished between reactive amines and protonated or poisoned surface amines on co-condensed SBA-15 materials. 

Preparation of Grafted Amine-Functionalized Silica. Silica was pressed, cmshed, and sieved to 40-60 mesh particles and calcined at 550°C overnight. To anhydrous toluene (40 mL), silica (1.0 g) was added under N2 and stirred for an hour. Aminopropyltriethoxysilane (APS 1.0 g, 5.58 mmol) was syringed into mixture and stirred for 24 hours at room temperature under nitrogen. The functionalized silica was then filtered, washed with toluene three times, and dried under vacuum at 50°C. 

Before the immobilization of 7b on silica, the support was modified with 3-aminopropyltriethoxysilane (3-APTES) (14). For complex iimnobihzation 0.06 g of 7b was dissolved in pyridine (20 mL), and the mixtnre was stirred for 7 h at room temperatnre. A snspension of 1 g of amino-modified silica in pyridine (10 mL) was stirred for 5 min in a ronnd bottom flask then, the complex-pyridine mixtnre was... 

Rhodamine B 67 is frequently used in the quantitative determination of DNA or RNA and fluorescent labeling for DNA [190-192]. This dye was assembled onto the surface of a quartz substrate by electrostatic interaction between the fluorescence reagent RB and y-aminopropyltriethoxysilane (APES), and the Quartz/ APES/RB film was constructed (Fig. 1) [193]. 

AV fj, flat-band-voltage change AV th threshold-voltage change RE reference electrode APTES 3-aminopropyltriethoxysilane. 

CNTs offer an exciting possibility for developing ultrasensitive electrochemical biosensors because of their unique electrical properties and biocompatible nanostructures. Luong et al. have fabricated a glucose biosensor based on the immobilization of GOx on CNTs solubilized in 3-aminopropyltriethoxysilane (APTES). The as-prepared CNT-based biosensor using a carbon fiber has achieved a picoamperometric response current with the response time of less than 5 s and a detection limit of 5-10 pM [109], When Nation is used to solubilize CNTs and combine with platinum nanoparticles, it displays strong interactions with Pt nanoparticles to form a network that connects Pt nanoparticles to the electrode surface. The Pt-CNT nanohybrid-based glucose biosensor... 

J.H.T. Luong, S. Hrapovic, D. Wang, F. Bensebaa, and B. Simard, Solubilization of multiwall carbon nanotubes by 3-aminopropyltriethoxysilane towards the fabrication of electrochemical biosensors with promoted electron transfer. Electroanalysis 16, 132-139 (2004). 

The formulation of the ORMOSIL precursor is chosen in the light of screening experiments (Figure 6.13). For the recognition of ovalbumin, for example, the precursor is a 55 mol% TEOS, 2 mol% 3-aminopro-pyltriethoxysilane (APTES), 3 mol% n-octyItrimethoxysi 1 ane (C8-TMOS) and 40 mol% bis(2-hydroxyethyl)aminopropyltriethoxysilane (HAPTS) mixture. The resulting microarray sensor exhibits analytical... 

The specific functionalization of the unprotected silica surface with a trialkoxysilane derivative such as CH3Si(OCH3)3 is then carried out in a slightly basic water-ethanol suspension of the snowman-like particles. TEM images (Figure 1.29) of the resulting suspension of latex nanoparticles whose unmodified part was further functionalized with a second trialkoxysilane such as aminopropyltriethoxysilane and then... 

Anodic EOF for CEC has also been obtained on a silica hybrid synthesized with the two coprecursors TEOS and 3-aminopropyltriethoxysilane (APTES) [97]. Here, no catalyst was added to accelerate the hydrolysis and condensation reactions ... 

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