4-Aminophenyl acetate

C. la Rosa, F. Pariente, L. Hernandez, and E. Lorenzo, Determination of organophosphorus and car-bamic pesticides with an acetylcholinesterase amperometric biosensor using 4-aminophenyl acetate as substrate. Anal. Chim. Acta 295, 273-282 (1993). 

The benzene ring has been proposed as an isosteric replacement in a dipeptide to enforce either the tram l1 1 or the cis conformation 312>31 (Scheme 1). Similarly, 2-(amino-methyl)pyrrole-l-acetic acid (8, R = H) has been proposed as a cis peptide bond mimic,141 having the same number of atoms between the amino and carboxylic acid functions as in a dipeptide. Several other amino- and carboxy-substituted aromatic structures have been used as spacers in peptides 2-, 3-, and 4-aminobenzoic acids (Abz, e.g., 7), 2-, 3-, and 4-(amino-methyl)benzoic acids (Amb, e.g., 2), 2-, 3-, and 4-(aminophenyl)acetic acids (APha, e.g., 5), 2- (4), 3-, and 4-(aminomethylphenyl)acetic acid (Ampa), (aminomethyl)pyrrole-, -thiophene-, and -furancarboxylic acids 6, (aminomethyl)pyrrole- 8 and -thienylacetic acids, and aminobiphenylcarboxylic acids. 

SCHEME 55.5. Hydrolysis reaction of 4-aminophenyl acetate by AChE. 

In a study of endothelin antagonists a potent compound (EMD 122801, H) was synthesized by the following route starting from (4-aminophenyl)acetic acid (X) ... 

FIGURE 62.8 The chemical structure of 4-aminophenyl acetate. FIGURE 62.9 The chemical structures of VX and sarin. 

In another report biosensors with cholinesterases immobilized on membranes were used in a FIA system. Paraoxon and carbaryl were determined with a detection limit of 0.1 M with 4-aminophenyl acetate as the substrate. A commercial Metrohm flow-through cell with a glassy carbon electrode was used. In such a system determinations in extracts from kiwi fruits treated with carbaryl were carried out. For a concentration of 3 ppm of the analyte in the extract a good agreement with the UV determinations was obtained. 

D(-)-0i-(Aminophenylacetamido)l penicillanic acid (Ampicillin) Metampicillin sodium Piperacillin sodium a-Aminophenyl acetic acid Ampicillin... 

Amino-4-nitrophenol, 25, 5 2-Amino-5-nitrotoluene, 20, 73 22, 44 (7/-ar-AMINOPHENYL ACETIC ACID, 22, 23 df-a-AMINO-a-PHENYLPROPIONIC ACID,... 

Polyfluoropolyacrylate 30% Pentadecafluorooctyl methacrylate 2% UV initiator 0.3% Dimethyl aminophenyl acetic acid 30 80" 4.40(1.64) ... 

Anilinosulfonium compounds of type 17 can also be used to synthesize indol-2(3. 0 Ones 19 starting from A -chloroanilines and (methylsulfanyl)acetic ester. The (o-aminophenyl)acetic esters 18 obtained via the S-ylide lead to indol-2(3//)-ones 19 after cyclization and reductive desulfurization. 

Figure 11.4 The effect of CTAB on the hydrolysis of four esters expressed as a ratio ( / o) of the first order rate constants obtained in the presence (/c ) and absence (/cq) of the surfactant. , EPAB A, PAPA , PNPA B, EPNB all in Delory and King s buffer O, EPAB in Sorensen s glycine buffer. The esters used were ethyl p-aminobenzoate (EPAB), p-nitrophenyl acetate (PNPA), ethyl p-nitrobenzoate (EPNB) and p-aminophenyl acetate (PAPA). From Meakin et al. [28].

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