BENZOIC ACID, 4-AMINO-3-METHYL

Benzoic acid, 4-amino-3-methyl-, ethyl ester]... 

BENZOIC ACID, 4-AMINO-3-METHYL-, ETHYL ESTER [40800-65-5], 15 Benzoic acid, 4-amino-3-[(methylthio)-methyl] -, ethyl ester [50461-34-2],... 

Metrizoic Acid. 3-(Acetylamino)-5-(acetylmethyl-amino)-2,4,6-triiodobenzoic acid 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido) benzoic acid N-methyl-3,5 -diacet-amido-2,4,6 triiodobenzoic acid. mol wt... 

Methoxy4,5-e2imido Benzoic Acid 1 -AI yl-2-amino-methyl Pyrrolidine Phosphoric Anhydride... 

A. Ethyl 4-Amino-3-(methylthiomethyl)benzoate [Benzoic acid, 4-amino-3-[(methylthio)methyl]-]. A 1-1., three-necked, round-bottomed flask is fitted with a mechanical stirrer, a condenser topped with a gas-inlet tube, and a two-neckcd adapter holding a low-temperature thermometer and a 100-ml., pressure-equalizing dropping funnel. The flask is charged with 10.50 g. (0.10 mole) of ethyl p-aminobenzoate [Benzocaine Benzoic acid, 4-amino-, ethyl ester] (Note 1), 300 ml. of acetonitrile, and 100 ml. of dichloromethane, is flushed with nitrogen, and is then immersed in a 40% aqueous methanol-dry ice bath maintained between... 

METHYL ESTER [24262-66-6], 59 Benzoic acid, 4-amino-, ethyl ester (94-09-7], 15,73... 

Benzoic acid,4-amino-3-[(methylthio)-methyl] -, ethyl ester, 15 Benzoic acid, 2-benzoyl-, methyl ester, 63 Benzoic acid, 4-bromo-, 86 Benzoic acid, 4-chloro-, 86 Benzoic acid, 2,4-dimethoxy-, 31 Benzoic acid, 3,4-dnnethoxy-, 31 Benzoic acid, 3,4-dimethyl-, 31 Benzoic acid, 3,5-dimethyl-, 86 Benzoic acid, 4-hydroxy-, 60 Benzoic acid, 2,4,6-tnmethyl-, 31 methyl ester, 63... 

Anisic acid, methyl ester [Benzoic acid, 4-methoxy-, methyl ester], 55, 40, 41 o-Amsidine [Benzenamine, 2-methoxy-], p-bromination of, 55, 23 [10] ANNULFNE, [ 1 l-Oxablcyclo[4 4 1]-undeca-l,3,5,7,9-pentaene], 55, 86 Anthramhc acid [Benzoic acid, 2-amino-], p-brominahon of, 55, 23 Apparatus, distillation of benzocyclopro-pene for, 55,13... 

Benzenesulfonyl chloride, 4-methyl- [p-Tol-uenesulfonyl chloride], 55, 57, 59 Benzenethiol [Phenol, thio-], 55, 122 Benzenethiol, copper(I) salt [Thiophenol, copper(I) salt], 55, 123 Benzenethiol, lithium salt [Thiophenol, lithium salt], 55, 1 22 Benzoic acid, 2-amino- [Anthramlic acid], p bromination of, 55, 23... 

CN rranj -2-[[[4-[[(aminoiminomethyl)amino]methyl]cyclohexyl]carbonyl]oxy]benzoic acid phenylmethyl ester... 

CN (5)-2-Ethoxy-4-[2-[[3-methyl-l-[2-(l-piperidinyl)-phenyl]butyl]amino]-2-oxoethyl]benzoic acid (S)-(+)-Ca salt... 

Soil. In unsterilized soils, 58% of C-labeled sulfometuron-methyl degraded after 24 wk. Metabolites identified were 2,3-dihydro-3-oxobenzisosulfonazole (saccharin), methyl-2-(amino-sulfonyl) benzoate, 2-aminosulfonyl benzoic acid, 2-(((aminocarbonyl)amino)sulfonyl) benzoate, and [ C]carbon dioxide. The rate of degradation in aerobic soils was primarily dependent upon pH and soil type (Anderson and Dulka, 1985). The reported half-life in soil was approximately 4 wk (Hartley and Kidd, 1987). 

In a recent modification of the second synthesis (50S) effected for fluvibactin (45) an o-xylene protection group was proposed (reaction of 2,3-dihydroxy-benzoic acid methyl ester with 1,2-di(bromomethyl)benzene) which could be removed later by hydrogenolysis. The formation of the oxazoline ring from protected DHB-L-threonine methyl ester was achieved with Mo(VI) catalysts (e.g. (NH4)2Mo04) without affecting the chiral centers. Derivatization of the primary amino groups of norspermidine with the protected DHB methyl ester was catalyzed by Sb(OC2115)3. 

Tetrahydrofolic acid then functions as a carrier of one-carbon groups for amino acid and nucleotide metabolism. The basic ring system is able to transfer methyl, methylene, methenyl, or formyl groups, and it utilizes slightly different reagents as appropriate. These are shown here for convenience, we have left out the benzoic acid-glutamic acid portion of the structure. These compounds are all interrelated, but we are not going to delve any deeper into the actual biochemical relationships. 

Indapamide Indapamide, 4-chloro-N-(2-methyl-l-indolinyl)-3-sulfamoylbenzamide (21.3.33), is synthesized from 2-methylendoline, the nitrosation of which gives 2-methyl-1-nitrosoindoline (21.3.31). Reducing this with lithium aluminum hydride leads to formation of l-amino-2-methylendoline (21.3.32). Acylating this with 3-sulfonylamino-4-chlor-benzoic acid chloride leads to (21.3.33) [53,54]. 

Cyclization of 2-[(3-acetamido-2-pyridyl)amino]benzoic acid (202) in 0.5 N sulfuric acid gave 6-amino-ll//-pyrido[2,l-h]quinazolin-ll-one (203) (84MI3). 2-[(6-Methyl-, 5-nitro-, and 3-nitro-2-pyridyl)amino]benzoic acids were cyclized into 9-methyl, 8-nitro, and 6-nitro-l 1 //-pyrido[2,l -ujquina-zolin-ll-ones, respectively, by the action of 80% sulfuric acid. Ethyl 2-(2-pyridylamino)benzoate, prepared in the reaction of 2-chloropyridine and ethyl anthranilate in boiling toluene for 10 h, afforded ll//-pyrido[2,l-b]-quinazolin-ll-one (27) on heating at 200-210°C for 0.5 h (92MI2). 

The benzene ring has been proposed as an isosteric replacement in a dipeptide to enforce either the tram l1 1 or the cis conformation 312>31 (Scheme 1). Similarly, 2-(amino-methyl)pyrrole-l-acetic acid (8, R = H) has been proposed as a cis peptide bond mimic,141 having the same number of atoms between the amino and carboxylic acid functions as in a dipeptide. Several other amino- and carboxy-substituted aromatic structures have been used as spacers in peptides 2-, 3-, and 4-aminobenzoic acids (Abz, e.g., 7), 2-, 3-, and 4-(amino-methyl)benzoic acids (Amb, e.g., 2), 2-, 3-, and 4-(aminophenyl)acetic acids (APha, e.g., 5), 2- (4), 3-, and 4-(aminomethylphenyl)acetic acid (Ampa), (aminomethyl)pyrrole-, -thiophene-, and -furancarboxylic acids 6, (aminomethyl)pyrrole- 8 and -thienylacetic acids, and aminobiphenylcarboxylic acids. 

Bis(trifluoromethyl)aniline on heating with sodium hydroxide gives 2-amino-4-(trifluoro-methyl)benzoic acid (4).170... 

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