Aminomethylation solid state structure

Later, Tieke reported the UV- and y-irradiation polymerization of butadiene derivatives crystallized in perovskite-type layer structures [21,22]. He reported the solid-state polymerization of butadienes containing aminomethyl groups as pendant substituents that form layered perovskite halide salts to yield erythro-diisotactic 1,4-trans polymers. Interestingly, Tieke and his coworker determined the crystal structure of the polymerized compounds of some derivatives by X-ray diffraction [23,24]. From comparative X-ray studies of monomeric and polymeric crystals, a contraction of the lattice constant parallel to the polymer chain direction by approximately 8% is evident. Both the carboxylic acid and aminomethyl substituent groups are in an isotactic arrangement, resulting in diisotactic polymer chains. He also referred to the y-radiation polymerization of molecular crystals of the sorbic acid derivatives with a long alkyl chain as the N-substituent [25]. More recently, Schlitter and Beck reported the solid-state polymerization of lithium sorbate [26]. However, the details of topochemical polymerization of 1,3-diene monomers were not revealed until very recently. 

Unaware of the above mentioned work we explored, almost at the same time, the similar theme and encountered some very interesting and novel findings about the synthesis and structure of (lithiomethyl)(aminomethyl)silanes. We are presenting new synthetic routes to (aminomethyl)silanes and (lithiomethyl)(aminomethyl)silanes and we want to give experimental information on two questions concerning (lithiomethyl)silanes (i) aggregation of (lithiomethyl)(aminomethyl)silanes in the solid state (ii) stabilizing effects of silicon in (lithiomethyl)silanes. 

Further related work on the synthesis, structure, and reactivity of (lithiomethyl)(aminomethyl)silanes is currently under way to understand more about the behavior of these systems in solution and in the solid state. 

A novel crystalline form of the boron-containing antibacterial drug (5 )-3-(aminomethyl)-7-(3-hydroxypropoxy)benzo[c][l,2]oxaborol-l(3H)-ol hydrochloride has been studied by solid-state NMR and single-crystal X-ray diffraction techniques. After determination of the crystal structure by X-ray diffraction, solid-state NMR spectroscopy of this form is performed to obtain structural information using experimental approaches based on dipolar correlation, chemical shift analysis, and quadrupolar interaction analysis. solid-state NMR experiments at 16.4 T using MAS and homonuclear dipolar decoupling, 2D solid-state NMR experiments based on and dipolar heteronuclear correlation, and DFT... 

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