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3-Aminobenzophenone compounds

SAR information about a series of 3-aminobenzophenone compounds (e.g. 6d and 6e), based on the mimic of the aminocombretastatin molecular skeleton, revealed that by the introduction of an amino group instead of a hydroxy group inhibition of tubulin polymerisation through binding to the colchicine binding site could fully be preserved or even improved [42]. [Pg.726]

In an alternate approach to the preparation of compounds containing the additional ring, haloamide, 41 (obtained from the aminobenzophenone and bromoacetylbromide) is alkylated with etha-nolamine to afford 42. Treatment of the amino alcohol in acetic acid affords the carbonyl addition product, 43, at the same time... [Pg.369]

It is interesting to note that the A1 -alkylbenzodiazepines can be analysed by a method that involves photodealkylation. The compounds are acid-hydrolysed to benzophenones and run on a plate to separate primary and secondary amines. The plate is then exposed to UV light for 10-15 min, which causes A-dealkylation, and run in the second dimension to identify the primary aminobenzophenones [230]. [Pg.112]

The antidepressant agent tampramine (44-6) can be viewed as a distant analogue of imipramine that contains an extra benzene ring and two additional nitrogen atoms. The preparation of this compound starts by Ullman coupling of chloropyridine (44-1) with the aminobenzophenone (44-2) more frequently used for benzodiazepine syntheses. Reduction of the nitro group in the product (44-3) leads to a diamine (44-4) that readily cyclizes to form the pyridodiazepine (44-5). Alkylation of the anion from the treatment of this with sodium hydride with 3-chloro-1 -dimethylaminopropane affords tampramine (44-6) [44]. [Pg.541]

Taylor and Heindel reacted several substituted o-aminobenzophenones and o-aminoacetophenones with DMAD the yields of the quinolones produced depend on the basicity of the starting amino compounds. They also reacted isatoic anhydrides (360) with DMAD in basic methanolic medium to obtain 4-quinolones (361).393... [Pg.406]

Benzodiazepines were the first class of heterocyclic compounds to be synthesized on the SynPhase surface. In 1994, Ellman and co-workers24 reported a 192 member library of structurally diverse 1,4-benzodiazepines. These compounds were prepared on Mimotopes pins that were grafted with polyacrylic acid, the surface originally used for antibody epitope elucidation.10 Ellman and co-workers25 subsequently synthesized a 1680-member 1,4-benzodiazepine library on SynPhase Crowns that were grafted with a methacrylic acid/dimethylacrylamide copolymer, one of the first SynPhase surfaces designed for solid-phase synthesis. The synthesis was performed on a preformed linker-template system in order to avoid low aminobenzophenone incorporation in this case the HMP acid-labile linker... [Pg.43]

A one-step synthesis of ( )-rutacridone (37) was achieved by the reaction of acridone (32 R = H) with isoprene dibromide isorutacridone (36), the isomer with linear annelation, was a minor product of the reaction (Scheme 5).19 A full account of the synthesis of acronycine from o-aminobenzophenones has now appeared (c/. Vol. 7, p. 90) and a modified route has been described (Scheme 6).20 Cyclization of the benzophenone derivative (38 R = Me) gave acronycine (39) (38%) and isoacronycine (40) (38%) a similar ring-closure of compound (38 R = H) furnished des-iV-methylacronycine. [Pg.92]

Phthalyl-p-aminobenzophenone.—This compound, by reduction in sulphuric-acid solution, gives a poor yield of pinacone. [Pg.207]

Chloro-3-arylanthranils have found a use as intermediates in the preparation of substituted 2-aminobenzophenones.225 Some substituted 4,5,6,7-tetrahydro compounds have been stated to be useful in antihistamine synthesis,332 and others tested against virus infections.333... [Pg.339]

A mild, highly efficient, scalable synthesis of 4-arylquinolin-2-ones from 2-aminobenzophenones was reported <03TL4271>. By reacting the starting material with lactones and two equivalents of LiHMDS, the desired compounds are formed in good to excellent yields. [Pg.325]

Two types of aromatic carbonyl compound give rise to lowest energy excited states not having (n, ti ) character. Amino substituted benzo-phenonra, especially, para-sul tituted compounds, form excited states which are neither (n, n ) nor (n, n ) in character, but which are better described as charge transfer states. A typical case is provided by p-aminobenzophenone whidi yields an excited state structure as shown ... [Pg.54]

Nearly a century ago, Posner obtained a material of empirical formula C7H5N from zinc chloride-catalyzed reduction of o-nitrobenzaldehyde. The compound, probably arising from intermediary o-aminobenzalde-hyde, was assigned either structure 137 or 114 (R = H) (1898CB658). [Compound 114 (R = H) has never been accessible from o-aminobenzal-dehyde for its synthesis, see Section II,C,2.] At about that time, Sond-heimer reacted o-aminobenzophenone with hydrochloric acid and obtained 6,12-diphenyldizenzo/6 //-1,5-diazocine (138, R-R6 = H)... [Pg.30]

Fig. 3.34 Influence of surface pH on the retention time of two test compounds, 2-aminobenzophenone (b) and 4-nitro-3-aminobenzophenone (a). Fig. 3.34 Influence of surface pH on the retention time of two test compounds, 2-aminobenzophenone (b) and 4-nitro-3-aminobenzophenone (a).
In contrast, oxidation of o-aminobenzophenone with lead tetraacetate under a variety of conditions yields only azo compound.171 However, the... [Pg.42]

An example of the approach used in combinatorial synthesis is the creation of a library of benzodiazepines. These compounds can be thought of as originating from three different sets of building blocks a substituted 2-aminobenzophenone, an amino acid, and an alkylating agent. [Pg.1223]


See other pages where 3-Aminobenzophenone compounds is mentioned: [Pg.385]    [Pg.44]    [Pg.891]    [Pg.624]    [Pg.508]    [Pg.683]    [Pg.396]    [Pg.683]    [Pg.784]    [Pg.44]    [Pg.624]    [Pg.301]    [Pg.333]    [Pg.8]    [Pg.683]    [Pg.31]    [Pg.31]    [Pg.33]    [Pg.166]    [Pg.24]    [Pg.103]    [Pg.283]    [Pg.283]    [Pg.331]    [Pg.114]    [Pg.71]    [Pg.29]    [Pg.247]    [Pg.262]    [Pg.107]   
See also in sourсe #XX -- [ Pg.726 ]




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2-Aminobenzophenone

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