6-Amino-o-cresol

Dinitro-3-amino-o-cresol 3,5-Dinitro-6-amino-2-hydroxy-toluene or 3,5-Dinitro-6-amino-2-hydroxy-l-methyl-benzene,... 

C7H802S ethyl thiophene-2-carboxylate 2810-04-0 491.15 43.034 1,2 10990 C7H9NO 3-amino-o-cresol 53222-92-7 480.51 42.014 2... 

Wu et al. reported the total synthesis of clausenaquinone A (112) using a palladium(ll)-mediated oxidative cyclization of the 2-arylamino-5-methoxy-l,4-benzoquinone 874 (107). This total synthesis was undertaken to establish the structure of natural clausenaquinone A (112). The key intermediate, 2-(3-hydroxy-4-methylanilino)-5-methoxy-l,4-benzoquinone (874), required for this synthesis, was obtained by the reaction of 5-amino-o-cresol (873) with 2-methoxy-l,4-benzoquinone (872) which was readily obtained by oxidation of methoxyhydroquinone (871). The palladium(ll)-mediated oxidative cyclization is non-regioselective. Thus, the cyclization of the 2-arylamino-5-methoxy-l,4-benzoquinone 874 with palladium(Il)... 

CAS 2835-95-2 EINECS/ELINCS 220-618-6 Synonyms 5-Amino-o-cresol 4-Amino-2-hyd roxy-1 -methylbenzene 3-Amino-6-methylphenol 5-Amino-2-methylphenol 3-Hydroxy-4-methylaniline 2-Hydroxy-p-toluidine 3-Hydroxy-p-toluidine ... 

BroKno-5-amino>o-cresol 3-Bromo-2 hydroxy-5. aminotoliiene). 

See under 3-Amino-p-cresoL o-Cresbl (o-Hydrgxytoluene, 6-rhethylphenol) CH,... 

Reaction of 2-amino-2-deoxypentoses with pentane-2,4-dione and 1-phenyl-butane-1,3-dione afforded substituted pyrroles (e.g., 41) and the riboflavin analogue (42) was prepared by condensation of l>-ribose with 5-amino-o-cresol, followed by cyclocondensation of the product with violuric acid. Reaction of dehydroascorbic acid with o-phenylenediamine followed by aroylhydrazides afforded compounds of the type (43), the side-chains of which have been further elaborated. The acid derived by oxidation of 2,3 4,5-di-0-iso-... 

Reduction with 0.55 mole of hypophosphorous acid gives some o-cresol, much tar, and no toluene.18 With 1.0 mole (104 cc.) of add, however, a 50% yield of pure toluene is obtained.82 If sulfuric acid is substituted for hydrochloric add, the yield falls to 12-23%.82, 7-Chlorohydrindone-l91 from 4-Amino-7-chlorohydrindone-l. A mechanically stirred suspension of 5.45 g. of 4-amino-7-chlorohydrindone-l, 12 cc. of concentrated hydrochloric acid, and 15 cc. of wateris cooled to 3°, and then a solution of 2.2 g. of sodium nitrite in 10 cc. of water is added over a period of thirty minutes. If necessary, a few grams of ice is added to maintain the temperature (usually 2-4 g. suffices). Stirring is continued for an additional five minutes, and then 100 cc. of 50% hypophosphorous acid (precooled to 0°) is run into the diazonium... 

Studies in animals reveal differences among species and between animals and humans. Maximum blood DNOC concentrations of 72.2 pg/g at 6 hours after the last dose of 20 mg/kg/day for 9 days and 105 pg/g at 3.5 hours after a single dose of 30 mg/kg DNOC were found in rats (King and Harvey 1953b). When rabbits were similarly treated, peak values were 54.7 pg/g at 4.5 hours after multiple doses of 25 mg/kg/day DNOC and 49.5 pg/g at 6 hours after a single dose of 30 mg/kg. Blood DNOC levels of 25, 34, and 50 pg/g were detected in rabbits given single oral doses of 10, 15, or 18 mg/kg DNOC, respectively (Truhaut and De Lavaur 1967). Urinary excretion of DNOC and its metabolite, 6-amino-4-nitro-o-cresol, accounted for 25-38% of the 10-15 mg/kg/day doses in 3 days. Of this, 87-97% was excreted in the first day. 

DNOC and its metabolite, 6-amino-4-nitro-o-cresol, which were detected in the urine of rabbits, made up 25-38% of the 10-15 mg/kg DNOC dose (Truhaut and De Lavaur 1967). Of this amount, 82-97% was eliminated within 1 day, and the rest was excreted within 2-3 days. As the dose of DNOC increased from 10 to 20 mg/kg, the ratio of 6-amino-4-nitro-o-cresol to DNOC in urine increased from 0.66 to 1.47 when measured at 2.5-3.75 hours after the dose. These ratios may be useful biomarkers of exposure to DNOC if the same phenomenon occurs in humans. 

Within 2 days after receiving a single dose of 20-30 mg/kg DNOC, Chinchilla rabbits excreted <20% of the dose as metabolites (Smith et al. 1953). Unchanged DNOC accounted for 5% of the dose and conjugated DNOC accounted for 1%. Derivatives of 6-amino-4-nitro-o-cresol comprised 11-12% of the dose, including 6-acetoamido-4-nitro-o-cresol (1-1.5% of the dose), O- conjugates of this metabolite (10% of the dose), and unspecified amounts of 3-amino-5-nitro-salicylic acid and derivatives of 4-amino-6-nitro-o-cresol that were also excreted in the urine. 

C7H6N604 5-(N-methyl-N-nitroso)amino-3-(5-nitro-2-fur 41735-28-8 25.00 1.6632 2 10525 C7H7CIO 5-chloro-o-cresol 5306-98-9 19.83 1.1954 2... 

Amino-2-chloro-6-methylphenol. See 5-Amino-6-chloro-o-cresol... 

Phenol acetate. See Phenyl acetate Phenol alcohol. See Phenol Phenol, o-allyl-. See 2-Allylphenol Phenol, 2-amino-. See o-Aminophenol Phenol, 3-amino-. See m-Aminophenol Phenol, 4-amino-. See p-Aminophenol Phenol, m-amino. See m-Aminophenol Phenol, 3-amino-2-chloro-6-methyl-. See 5-Amino-6-chloro-o-cresol... 

Bis [(octylthio) methyl]-o-cresol 4-[[4,6-Bis (octylthio)-s-triazin-2-yll amino)-2,6-di-t-butylphenol Calcium bis fmonoethyl (3,5-di-t-butyl-4-hydroxybenzyl) phosphonate] ... 

Am i no-6-chloro-o-cresol 2-Am ino-3-hydroxypyridi ne 4-Am i no-2-hyd roxytol uene 2-Amino-3-nitrophenol 2-Amino-5-nitrophenol... 

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