Salicylic acid, 5-Nitro

Erdmann and Uhrich (2000 Erdmann et al., 2000) recently synthesized novel poly(anhydride-co-ester)s containing salicylic acid in the backbone, by melt polycondensation of the disalicylic acid ester of sebacic acid, poly[bis(o-carboxyphenoxy)sebacate] (PCPS) and the copolymer P(CPH-CPS). The release of salicylic acid (the active form of aspirin) from the former was studied in vitro and from the latter was studied in vivo (Erdmann and Uhrich, 2000 Erdmann et al., 2000). Similar polymers that release 5-amino salicylic acid, and p-nitro salicylic acid have been prepared... 

The catalytic reduction of o-nitrophenol by the surface of a Ti(IV)/Ti(III) redox system on a Ti/Ti02 electrode has been used in a preparative-scale operation [522]. 5-Nitro-salicylic acid [523] and... 

Diazosalicylic acid and derivs 5 D1175 3-chloro 5-diazosalicylic acid 5 D1175 3-chloro-5-diazosalicylic acid 5 D1175 3-diazo-5-nitro-salicylic acid 5 D1175... 

Within 2 days after receiving a single dose of 20-30 mg/kg DNOC, Chinchilla rabbits excreted <20% of the dose as metabolites (Smith et al. 1953). Unchanged DNOC accounted for 5% of the dose and conjugated DNOC accounted for 1%. Derivatives of 6-amino-4-nitro-o-cresol comprised 11-12% of the dose, including 6-acetoamido-4-nitro-o-cresol (1-1.5% of the dose), O- conjugates of this metabolite (10% of the dose), and unspecified amounts of 3-amino-5-nitro-salicylic acid and derivatives of 4-amino-6-nitro-o-cresol that were also excreted in the urine. 

Nitro salicylic acid m-Nitrobenzoic acid Salicylic acid Benzoic acid Phenylbutazone o-Nitrophenol Thiopental... 

The nitro-salicylic acid is reduced to amino-salicylic acid by the action of sulphurous acid formed by interaction of sulphuric acid and sodium thiosulphate. 

Dinitrosalicylic acid proved to be an excellent oxidizing agent for measuring very low amylase activities. The colorimetric response results from the conversion of 3,5-dinitrosalicylic acid to 3-amino-5-nitro-salicylic acid. The color produced by this reduction reaction is proportional to the actual number of reducing groups generated. 

Anantharaman, R N. Vasudevan, D. Chellammal, S. An improved process for the preparation of 5-aminosalicylic acid by using Titanium/Titania cathode in the electrochemical reduction of 5-nitro-salicylic acid in aqueous ethanolic solutions. Indian IN 184281, 2000 Chem. Abstr. 2004, 141, 277357. 

After moistening the sample with digestion mixture (4.6), at least 2 h are needed for the nitro-salicylic acid compounds to be formed in the authors laboratory this period is often taken overnight. 

At least 2 h at 100 °C is necessary to obtain complete reduction of the nitro-salicylic acid compounds. 

After moistening the sample with the digestion mixture (4.4), at least 2 h is needed to form the nitro-salicylic acid compounds. A longer period (overnight), however, will prevent foaming later on. When heating at 180 " C, the sample will turn black and foam may be formed. If this reaches the neck of the flask, 1 or 2 drops of hydrogen peroxide (4.2) should be added. 

Name some other organic reagent that is employed in place of zinc for the reduction of nitro.salicylic acid. 

Hydroxybenzoic Acid, 3-Diazo-5-nitro or 3-Diazo-5-Nitro-Hydroxybenzoic Acid (called 5-Nitro-3-diazo-salicyls aure in Ger). 

Benzyl salicylate can be prepared by the reaction of benzyl chloride with an alkali salt of salicylic acid at 130—140°C or by the transesterification of methyl salicylate with benzyl alcohol. It is used as a fixative and solvent for nitro musks and as a fragrance for deteigents. Benzyl salicylate was priced at... 

The blue component (H acid — cresidine—>H acid) is linked with the triazine ring by means of the amino group of the H acid after reduction of the nitro group, the yellow component (j9-nitroaniline —> salicylic acid) replaces the second chlorine atom of cyanuric chloride, and aniline the third chlorine atom. The dye constitutes a very pure, clear, bluish green with very good fastness properties. 

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