4- amino-3-hydroxybenzoate

C13H11N03 phenyl 4-amino-3-hydroxybenzoate 133-11-9 25.00 1.2508 2 25879 C13H13N05 3-(4-hydroxyphenyl)propionic acid N-hydroxys 34071-95-9 25.00 1.2936 2... 

Compound 10 has been synthesised utilising as a starting material commercially available 4-amino-3-hydroxybenzoic acid 10a (Scheme M). 

A series of new esters of 4-amino-3-hydroxybenzoic acid with... 

Note The name Orthoform was applied originally to the methyl ester of 4-amino-3-hydroxybenzoic add, mp 121, which was also used as a local anesthetic. This compd now is desiguated as Orthoform Old. 

Phenyl 4-amino-3-hydroxybenzoate Phenyl p-aminosalicylate C13H11NO3 133-11-9 229.231 163 ... 

Phenyl-5-allyl-2.4.6(1/y.3/y.5/y)-pyrimidinetrione 4-(Phenylamino)benzenesulfonicacid 2-(Phenylamino)benzoicacid Phenyl 4-amino-3-hydroxybenzoate... 

The enzyme-mediated transformation of a hydroxylamino arene into an ortho-2Vcm-nophenol corresponds to a chemical rearrangement known as the Bamberger reaction (25), which generates the 4-aminophenol from hydroxylaminobenzene under acidic conditions. It is likely that this intermolecular rearrangement proceeds via an arylnitrene, which by the additional function of a hydroxylamino lyase can generate protocatechuate plus ammonia rather than 4-amino-3-hydroxybenzoate from 4-hydroxylaminobenzoate. 

By feeding [7- C]3-amino -hydroxybenzoic acid (3,4-AHBA) 242 to liquid cultures of S. nodosus ssp. asukaensis ATCC 29757 and also to S. parvulus Tii 64, intact incorporation of 242 into the manumycins was observed, which showed that 3,4-AHBA indeed serves as the polyketide starter unit for the formation of the lowei chain. 

Mesalamine. Rowasa, Asacol, and Pentasa are trade names for mesalamine [89-57-6] (5-ASA, 5-amino-2-hydroxybenzoic acid). It is a white to pinkish crystalline substance that is slightly soluble in cold water and alcohol, more soluble in hot water, and soluble in hydrochloric acid. It may be prepared by the reduction of y -nitrobenzoic acid with zinc dust and HCl. 

Amino-2-hydroxybenZOiC acid. This derivative (18) more commonly known as 4-aminosa1icy1ic acid, forms white crystals from ethanol, melts with effervescence and darkens on exposure to light and air. A reddish-brown crystalline powder is obtained on recrystallization from ethanol —diethyl ether. The compound is soluble ia dilute solutioas of nitric acid and sodium hydroxide, ethanol, and acetone slightly soluble in water and diethyl ether and virtually insoluble in benzene, chloroform or carbon tetrachloride. It is unstable in aqueous solution and decarboxylates to form 3-amiaophenol. Because of the instabihty of the free acid, it is usually prepared as the hydrochloride salt, mp 224 °C (dec), dissociation constant p 3.25. 

Amino-2-hydroxybenzoic acid is manufactured by carboxylation of 3-amiaophenol under pressure with ammonium carbonate at 110 °C (182) or with potassium bicarbonate and carbon dioxide at 85—90°C (183) with subsequent acidification. 

The ansa-chain of the ansamycins streptovaricins (4), rifamycins (263), geldanamycin (4), and herbimycin (32) has been shown to be polyketide in origin, being made up of propionate and acetate units with the 0-methyl groups coming from methionine. The remaining aromatic C N portion of the ansamacroHdes is derived from 3-amino-5-hydroxybenzoic acid (264—266) which is formed via shikimate precursors. Based on the precursors of the rifamycins and streptovaricins isolated from mutant bacteria strains, a detailed scheme for the biosynthesis of most of the ansamacroHdes has been proposed (95,263). 

Aminosalicylic acid (5-amino-2-hydroxybenzoic acid) [89-57-6] M 153.1, m 276-280 , 283 (dec), pK 2.74 (CO2H), pK 5.84 (NH2). Cryst as needles from H2O containing a little NaHS03 to avoid aerial oxidation to the quinone-imine. The Me ester gives needles from C6H6, m 96°, and the hydrazide has m 180-182° (From H2O). [Fallab et al. Helv Chim Acta 34 26 1951, Shavel J Amer Pharm Assoc 42 402 1953.]... 

Attempts to prepare 6-hydroxybenzofuroxan by demethylation of 5-methoxybenzofuroxan, by pyrolysis of 4-azido-3-nitrophenol, and by hypochlorite oxidation of 4-amino-3-nitrophenoD failed. This rather unstable compound was finally prepared by hydrolysis of 5-acetoxybenzofuroxan its tautomeric possibilities are numerous, but from the similarity of its ultraviolet spectrum to that of 5-methoxybenzofuroxan it was considered to be largely in the hydroxy form. It is a fairly strong acid, of pK 6.76 (cf. 5-hydroxybenzo-furazan, pK 7.28). 7-Hydroxy-4,6-dinitrobenzofuroxan has been reported as arising from oxidation and nitration of dinitrosoresorcinol monooxime (tetraoxocyclohexene trioxime). ... 

Chemical Name 4-amino-2-hydroxybenzoic acid Common Name —... 

Therapeutic Function Antibacterial (Tuberculostatic) Chemical Name 4-Amino-2-hydroxybenzoic acid phenyl ester Common Name Fenamisal Structural Formula cc... 

Figure 11.5 3-Amino-5-hydroxybenzoic acid as a precursor to the porfiromycin C quinone. 

Figure 11.6 The aminoshikimate pathway to 3-amino-5-hydroxybenzoic acid.

CN 5 [[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxybenzoic acid disodium salt ( )-free acid... 

RN 2066-89-9 MF C7H7NO3 C,H,N30 MW 290.28 EINECS 218-183-2 CN 4-pyridinecarboxylic acid hydrazide mono(4-amino-2-hydroxybenzoate)... 

CN a-[[bis( 1 -methylpropyl)amino]methyl]-1 -[(2-chlorophenyl)methyl]-1 //-pyrrole-2-methanol p-hydroxybenzoate (1 1)... 

In the aligned primary structures of class I decarboxylases, the conserved amino acid residues are scattered over their primary structures. There have been few reports to identify the amino acid residues essential for catalytic activity or substrate binding. Huang et al. reported the E-X-P motif in the alignment analysis for 4-hydroxybenzoate decarboxylase of C. hydroxybenzoicum and its homologous unidentified proteins. The E-X-P motif is also conserved in pyrrole-2-carboxylate decarboxylase and indole-3-carboxylate decarboxylase (unpublished data). However, the corresponding motif sequence is not observed in the primary structures of 3,4-dihydroxybenzoate decarboxylase of E. cloacae P241. ... 

Cell-free supernatants may mediate reductions. The reduction of aromatic nitro compounds by SH was mediated by the hltrate from a strain of Streptomyces sp. that is known to synthesize 2-amino-3-carboxy-5-hydroxybenzo-l,4-quinone (cinnaquinone)... 

Replacement of the hydroxyl group on the phenyl ring with a carboxyl group forms a molecule of benzoic acid. Addition of a hydroxyl at the 2-position on a benzoic acid molecule forms 2-hydroxybenzoic acid or salicylic acid. The slightly more complex phenylpropanoid skeleton contains a linear three-carbon chain (the propanoic group) added to the benzene ring (the phenyl group). Addition of ammonia to carbon 2 of this three-carbon side chain yields the amino acid phenylalanine (Fig. 3.3). Phenylalanine... 

The choice of a matrix tailored for a particular kind of polymer sample is cmcial for successful characterization of the sample. Therefore, it is useful to discuss the properties of some common matrices [4—6], 3-Amino-4-hydroxybenzoic acid and POPOP need high laser power, since they possess a high threshold. Alpha-cyanocynnamic acid is... 

Amino-2-hydroxybenzoic acid, 2 668-669 physical properties of, 2 666t 2-Amino-2-(hydroxymethyl)-1,3-propanediol... 

The mixed anhydride method was used with diaminoethane to give a free amino group that was subsequently reacted with 4-hydroxybenzoic acid to provide an aromatic ring to allow iodination with [ ] to increase sensitivity of the assay compared with labelled radioactive tracers. This reaction could also be used to prepare fluorescent compounds for cell-biology studies. 

Lau and Gompf359 prepared a series of 2-amino-6-hydroxybenzo[d]-thiazoles and corresponding naphtho[l,2-d]thiazoles on treating 1,4-benzoquinone and 1,4-naphthoquinone with thiourea in acidic media at room temperature. At high temperature the products of the reaction with 1,4-benzoquinone are 5-hydroxy benz[d]-l,3-oxathiol-2-ones... 

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