Hydroxybenzoic acid phenyl ester

Therapeutic Function Antibacterial (Tuberculostatic) Chemical Name 4-Amino-2-hydroxybenzoic acid phenyl ester Common Name Fenamisal Structural Formula cc... 

Synonyms cas 118-55-8 salol 2-hydroxybenzoic acid phenyl ester Phloroglucinol... 

See Phenoxyethylparaben 2-Hydroxybenzoic acid phenyl ester. See Phenyl salicylate... 

Hydroxybenzoic acid, phenyl ester p-Hydroxybenzoic acid, phenyl ester. See Phenylparaben... 

CAS 17696-62-7 EINECS/ELINCS 241-698-9 Synonyms Benzoic acid, 4-hydroxy-, phenyl ester 4-Hydroxybenzoic acid, phenyl ester p-Hydroxybenzoic acid, phenyl ester Phenyl 4-hydroxybenzoate... 

Synonyms 2-Hydroxybenzoic acid phenyl ester Phenyl-2-hydroxybenzoate Salol... 

Phenyl 5-benzoyl-2-hydroxybenzoate 5-Benzoyl-2-hydroxybenzoic acid phenyl ester... 

B enzoy loxy) -2-hy droxypheny l]pheny Imethanone, 129 (2,3-Dihydroxy-1,4-phenylene)bis[phenyhnethanone, 535 (2,4-Dihydroxy-1,3 -phenylene)bis [phenyhnethanone, 544 (2,5-Dihydroxy-1,4-phenylene)bis [phenyhnethanone, 544 (3,4-Dihydroxy-1,2-phenylene)bis [phenyhnethanone, 545 (4,6-Dihydroxy-1,3 -phenylene)bis [phenyhnethanone, 536 Phenyl 5-benzoyl-2-hydroxybenzoate, 130 5-Benzoyl-2-hydroxybenzoic acid phenyl ester, 130... 

Benzyl Salicylate, 2-Hydroxybenzoic acid phenyl methyl ester salicylic acid benzyl ester. CKH mol wt 228.24. C 73.677°, H 5.307°, O 21.03%. Prepd from sodium alkylate and benzyl chloride Volwiler, Vliet, J. Am. Chem. See 43, 1672 (1921). 

Hydroxybenzoic acid, 4 (acetylamino) phenyl-, ester. See Acetaminosalol 2-Hydroxybenzoic acid, 2-[bis-(2-hydroxyethyl) amino] ethanol. See TEA-salicylate 2-Hydroxybenzoic acid bismuth (3+) salt basic. See Bismuth subsalicylate 2-Hydroxybenzoic acid, butyl ester. See Butyl salicylate... 

Synonyms 2-hydroxybenzoic acid phenylmethyl ester salicylic acid benzyl ester benzyl o-hydroxybenzoate 2-hydroxybenzoic acid phenyl methyl ester... 

Perfumes, Flavors, Cosmetics, and Soap. Many naturally occurring esters in essential oils and some synthetic esters are important fragrance and flavor compounds (61,62). They are used in perfumes, flavors, cosmetics, soaps, detergents, and air fresheners. Benzyl, butyl, ethyl, methyl, and phenyl esters of benzoic acid are used as flavors, perfumes, and food preservatives. Glyceryl 4-aminobenzoate [136-44-7] and 2-ethyUiexyl 4-dimethylaminobenzoate [21245-02-3] are used in cosmetic sunscreen preparations. Alkyl esters of 4-hydroxybenzoic acid, called parabens, have been used under various names for fungus infections of the skin, and as preservatives in lotions and creams (101). Soap and cosmetic fragrances use large amounts of amyl and benzyl saHcylate. Benzyl saHcylate [118-58-1] is also used in deodorant sprays. 2-Ethylhexyl saHcylate [118-60-5] and 2-ethylhexyl 4-methoxycinnamate [5466-77-3] are used in sunscreen formulations (102). 

In the 1960s the Carborundum company introduced the polymer Ekonol P-3000. This was the polymer of p-hydroxybenzoic acid (I) Figure 25.22), in practice produced by the self-ester exchange of its phenyl ester to prevent decarboxylation. A blend with PTFE, Ekonol T-4000, was also produced. 

Poly(arylene ether benzoxazole)s were also synthesized from the reaction of bis[(4-hydroxyphenyl)benzoxazole]s and activated aromatic difluoro monomers as shown in Eq. (7) [28,29]. The bis[(4-hydroxyphenyl)benzoxazole]s were readily prepared by condensation of the appropriate bis(o-aminophenol) (e.g. 3,3 -dihydroxy-4,4 -diaminobiphenyl) with phenyl-4-hydroxybenzoate in diphenyl sulfone at 260°C. Under proper conditions, the less expensive 4-hydroxybenzoic acid can be used in place of the phenyl ester to provide high yields of the desired bis[(4-hydroxyphenyl)benzoxazole]s. As presented in Table 9, the hexafluoroisopropylidene (6F) containing polymers were amorphous. These polymers were prepared in DMAc. However, the polymers derived from 6,6 -bis[2-(4-hydroxyphenyl)benzoxazole] were prepared in diphenyl sul-... 

Chemical Name 2-Hydroxybenzoic acid 4-(acetylamino)phenyl ester... 

SYNS BENZOIC ACID, 2-HYDROXY-, 4-METHYL-PHENYL ESTER (9CI) p-CRESYL SAUCYLATE 4-METHYLPHENYL 2-HYDROXYBENZOATE 4-METHYLPHENYL SALICYLATE SAUCYUC ACID. p-TOLYL ESTER... 

BHT is cleared less rapidly from most species, enterohepatic circulation being partly responsible for the delay. The major metabolites of BHT in rat urine are 3,5-di-Tbutyl-4-hydroxybenzoic acid (BHT acid III), both free (90% of the dose) and as a glucuronide (15%), and S-(3,5-di-Tbutyl-4-hydroxybenzyl)-N-acetylcysteine. The ester glucuronide and mer-capturic acid were major metabolites in rat bile, while free BHT acid was the main component in the feces. In addition, l,2-bis(3,5-di- -butyl-4-hydroxy-phenyl) ethane has been identified in rat bile. In BALB/c mice, 75% of a single oral dose was excreted in the urine during the first 24 h this was followed by a slower phase during which an additional 10% was excreted over the next 4 days. The total amount found in the feces was less than 1%. Female rats have greater urinary excretion of BHT than male rats, whereas male BALB/c mice excreted BHT more rapidly than females. 

The usual techniques of polyesterification, such as the solution31 or interfacial32 reaction between an aromatic acid chloride and bisphenol, are not applicable to the preparation of poly (phenyl esters) from hydroxybenzoic acids (prepared by an acid or phenyl ester exchange reaction of the acetate or phenyl ester of the acid33 ). 

In the 1960s the Carborundum Company introduced the homopolymer of p-hydroxybenzoic acid under the trade name Ekonol [35]. It is used in plasma coating. This wholly aromatic homopolyester is produced in practice by the self-ester exchange of the phenyl ester of p-hydroxybenzoic acid. 

Benzoic acid, 3,5-bis (1,1-dimethylethyl)-4-hydroxy-, 2,4-bis (1,1-dimethylethyl) phenyl ester. See 2,4-Di-t-butylphenyl 3,5-di-t-butyl-4-hydroxybenzoate... 

Benzoic acid ethyl ester. See Ethyl benzoate Benzoic acid, 4-(((ethylphenylamino) methylene) amino)-, ethyl ester. See N-(p-Ethoxycarbony I phenyl )-N -ethy l-N -phenylformamidine Benzoic acid, hexahydro-. See Cyclohexanecarboxylic acid Benzoic acid, hexyl ester. See Hexyl benzoate Benzoic acid, 4-hydroxy- Benzoic acid, p-hydroxy-. See 4-Hydroxybenzoic acid Benzoic acid, 2-hydroxy-, butyl ester. See Butyl salicylate... 

CAS 94-18-8 EINECS/ELINCS 202-311-9 Synonyms Benzoic acid, 4-hydroxy-, phenyl methyl ester Benzyl 4-hydroxybenzoate Benzyl p-hydroxybenzoate Phenylmethyl 4-hydroxybenzoate Definition Ester of benzyl alcohol and p-hydroxybenzoic acid Empirical C14H12O3 Toxicology TSCA listed Uses Preservative, bactericide, fungicide for foods, pharmaceuticals, industrial applies. antimicrobial in cosmetics Regulatory BP compliance Manuf./Distrib. Aldrich http //www.sigma-aldrich.com-, Alfa Aesar http //www.aifa.com-, Archimica Inc http //www.archimica.com-. 

Di-t-butyl-p-hydroxybenzoic acid 1,5-Dioxaspiro [5.5] undecane 3,3-dicarboxylic acid, bis (2,2,6,6-tetramethyl-4-piperidinyl) ester 4-Dodecyloxy-2-hydroxybenzophenone 2-(2 -Hydroxy-3,5 -di-t-amylphenyl) benzotriazole Phenyl salicylate UV absorber, PET... 

The direct polycondensation of p-hydroxybenzoic acid at the required temperatures of above 200° C leads to decarboxylation. Consequently, the phenyl ester is commercially polycondensed in terphenyl as solvent since a good heat conduction is absolutely necessary for high yields. 

Zlatoidsky (50) recently described the synthesis of N-protected a-amino aldehydes via reduction of the corresponding phenyl esters by lithium tri(tert-butoxy)aluminium hydride. Since 4-hydroxybenzoic acid is commercially available, we decided to explore this reaction in the soUd phase strategy. 

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