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Amine oxides hydrazones

Nickel peroxide is a solid, insoluble oxidant prepared by reaction of nickel (II) salts with hypochlorite or ozone in aqueous alkaline solution. This reagent when used in nonpolar medium is similar to, but more reactive than, activated manganese dioxide in selectively oxidizing allylic or acetylenic alcohols. It also reacts rapidly with amines, phenols, hydrazones and sulfides so that selective oxidation of allylic alcohols in the presence of these functionalities may not be possible. In basic media the oxidizing power of nickel peroxide is increased and saturated primary alcohols can be oxidized directly to carboxylic acids. In the presence of ammonia at —20°, primary allylic alcohols give amides while at elevated temperatures nitriles are formed. At elevated temperatures efficient cleavage of a-glycols, a-ketols... [Pg.248]

Aldehyde-containing macromolecules will react spontaneously with hydrazide compounds to form hydrazone linkages. The hydrazone bond is a form of Schiff base that is more stable than the Schiff base formed from the interaction of an aldehyde and an amine. The hydrazone, however, may be reduced and further stabilized by the same reductants utilized for reductive amination purposes (Chapter 3, Section 4.8). The addition of sodium cyanoborohydride to a hydrazide-aldehyde reaction drives the equilibrium toward formation of a stable covalent complex. Mallia (1992) found that adipic acid dihydrazide derivatization of periodate-oxidized dextran (containing multiple formyl functionalities) proceeds with much greater yield when sodium cyanoborohydride is present. [Pg.140]

Amide reduction with lithium aluminum hydride, 39, 19 Amine oxide formation, 39, 40 Amine oxide pyrolysis, 39, 41, 42 -Aminoacetanilide, 39, 1 Amino adds, synthesis of, 30, 7 2-Amino-4-anilino-6-(chloro-METHYl) -S-TRIAZINE, 38, 1 -Aminobenzaldehyde, 31, 6 hydrazone, 31, 7 oxime, 31, 7 phenylhydrazone, 31, 7 > -Aminobenzoic add, 36, 95 2-Aminobenzophenone, 32, 8 c-Aminocaproic acid, 32, 13 6-Aminocaproic acid hydrochloride,... [Pg.83]

The carbonyl group is a reactive function and, although aromatic aldehydes are somewhat less reactive than their aliphatic counterparts, benzaldehydes have an extensive chemistry. Many reactions replicate those of aliphatic aldehydes, but are mentioned here for completeness. Thus, oxidation of the carbonyl group leads to carboxylic acids and reduction gives alcohols. The aldehyde group reacts with a range of N-nucleophiles (Scheme 6.9). Imines (Schiff bases) are formed with amines and hydrazones with hydrazines. Semicarbazide gives semicarbazones and hydroxylamine forms oximes. [Pg.71]

Platinum oxide Amines from hydrazones s. 3, 39 PtO, C NNHR -> CHNH2... [Pg.274]

An intramolecular Cu(OAc)-catalyzed aerobic oxidative C(sp )-H amination of hydrazones to pyrazoles and indazoles using 2(1 atm) as the sole oxidant is reported by Jiang and coworkers (Scheme 8.66). A broad substrate scope and good functional group tolerance show that this aerobic oxidative transformation shows... [Pg.260]

Basic Red 22 (134), which contains 1 part ia 7 of the yellowish red 1,4-dimethyl isomer, Basic Red 29 (135), and Basic Yellow 25 (136) are all examples of delocalized cationic azo dyes. Dyes of this type can also be synthesized by Hbnig s oxidative coupling reaction of heteroaromatic hydrazones with tertiary aromatic amines. [Pg.454]

Reduction, carboxyl groups, 56,83 Reduction of a,0-unsaturated p-toluene-sulfonyl-hydrazones to alkenes, 59,42 Reductive alkylation, 56,52 Reductive cleavage, 56, 101 Resolution of amines, 55,80, 83 Rexyn 201,55,4 Rhodium(III) oxide, 57, 1 Ring contraction, 56, 107 Ring expansion of cycloalkanones to cycloalkenones, 59, 113... [Pg.121]

El-Kommos and Emara [44] described a spectrophotometric method, for the determination of primaquine and other secondary aromatic amines pharmaceuticals, using 3-methylbenzothiazolin-2-one hydrazone. The method is based on oxidative coupling reaction of 3-methylbenzothiazolin-2-one hydrazone. [Pg.181]

Figure 5.35 ABH reacts with aldehyde-containing compounds through its hydrazide end to form hydrazone linkages. Glycoconjugates may be labeled by this reaction after oxidation with sodium periodate to form aldehyde groups. Subsequent photoactivation with UV light causes transformation of the phenyl azide to a nitrene. The nitrene undergoes rapid ring expansion to a dehydroazepine that can couple to nucleophiles, such as amines. Figure 5.35 ABH reacts with aldehyde-containing compounds through its hydrazide end to form hydrazone linkages. Glycoconjugates may be labeled by this reaction after oxidation with sodium periodate to form aldehyde groups. Subsequent photoactivation with UV light causes transformation of the phenyl azide to a nitrene. The nitrene undergoes rapid ring expansion to a dehydroazepine that can couple to nucleophiles, such as amines.
Several approaches to the 1,2,3-triazole core have been published in 2000. Iodobenzene diacetate-mediated oxidation of hydrazones 152 led to fused 1,2,3-triazoloheterocycles 153 <00SC417>. Treatment of oxazolone 154 with iso-pentyl nitrite in the presence of acetic acid gave 1,2,3-triazole 155, a precursor to 3-(W-l,2,3-triazolyl)-substituted a,P-unsaturated a amino acid derivatives <00SC2863>. Aroyl-substituted ketene aminals 156 reacted with aryl azides to provide polysubstituted 1,23-triazoles 157 <00HC387>. 2-Aryl-2T/,4/f-imidazo[43-d][l,2,3]triazoles 159 were prepared from the reaction of triethyl AM-ethyl-2-methyl-4-nitro-l//-imidazol-5-yl phosphoramidate (158) with aryl isocyanates <00TL9889>. [Pg.180]

Lead tetraacetate, oxidation of a hydrazone to a diazo compound, 50, 7 Lithio ethyl acetate, 53, 67 Lithium, reductions in amine solvents, 50, 89 Lithium aluminum hydride, reduction of exo-3,4-dichloro-bicyclo-[3.2.l]oct-2-ene to 3-chlorobicyclo[3.2.l]oct-2-ene, 51, 61... [Pg.131]

Whereas the reactions of allenephosphonates 171 (R2 = OEt) with primary aliphatic and aromatic amines 172 and the reactions of the phosphane oxides 171 (R2 = Ph) with aliphatic amines 172 afford the conjugated addition products 173 always in good yields, the addition of anilines to 171 (R2 = Ph) leads to an equilibrium of the products 173 and 174 [231]. However, treatment of both phosphane oxides and phos-phonates of type 171 with hydroxylamines 172 (R3 = OR4) yields only the oximes 174 [232, 233]. The analogous reaction of the allenes 171 with diphenylphosphinoylhy-drazine furnishes hydrazones of type 174 [R3 = NHP(0)Ph2] [234],... [Pg.382]

Pentafluoronitrosobenzene, 363, 410 Pentyl azide, 271 Peracid oxidation of amines, 323, 363,409 of azo compounds, 355-356 of hydrazones, 362 of hydroxylamines, 364,415 of imines, 406 of oxaziranes, 407 Perchloryl fluoride, 336 Perfluoroalkylureas, 162 Perfluoro-2-azopropene, oxidation of, 432 Periodic acid oxidation, 338 Permonosulfuric acid, see Caro s acid Phenazines, 321... [Pg.253]

Methyl-3-phenyl-l,2,4-thiadiazol-5-one hydrazone contains the amidrazone group necessary for oxidative coupling with suitable phenols or amines to yield azo-dyes. Thus, condensation products (288... [Pg.181]

Tertiary amines are oxidized to the corresponding nitrogen oxides. Tosyl hydrazones of ketones and aldehydes and imines are oxidized to the corresponding carbonyl compounds. Reactions have been carried out with small molecules and also with molecules that would not diffuse into the pore structure of the titanium silicates. As in the case of C—C bond cleavage, it is possible that these reactions take place on the outer surface of the catalyst crystals. [Pg.316]


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See also in sourсe #XX -- [ Pg.29 , Pg.399 ]




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Oxidation hydrazone

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