Amination diamination

These are often crystaUine and therefore useful for the characterisation of primary amines. Diamines may, of course, yield di benzal derivatives. 

Sulfur The yellow, orange, and brown sulfur dyes belong to this group. The dyes are usually made from aromatic amines, diamines, and... 

Diketimines can be prepared by condensation of 1,2-diketones with 2 equiv of an amine, or 1 equiv of a 1,2-diamine, by azeotropic removal of water. Either a chiral diketone or a chiral amine/diamine can be used in order to obtain a chiral diimine. In both cases, the use of 1,2-diamines is expected to provide better stereocontrol, because of the rigidity of the derived cyclic diimines. For example, the reaction of camphor 1,2-diketone 275 and racemic 1,2-diphenylethylenediamine (d,l)-26 gave the diimine 276 as a mixture of two diastereomers (Scheme 45) [138]. Reduction of 276 with sodium borohydride followed by hydrogenolysis of the N substituents afforded the camphordiamine, which was isolated as the dihydrochloride... 

High boiling polar compounds, diols, phenols, methyl esters of. dicarboxylic acids, amines, diamines, ethanolamines, amides, aldehydes and ketones. 

The nitration of 1,1,2,2-tetraiodoethylene (182) with 90% nitric acid provides 1,1-diiododinitroethylene (183) in good yield. Baum and co-workers studied the chemistry of 1,1-diiododinitroethylene and found that displacement of the two vinylic iodide groups is effected by treatment with simple aliphatic amines, diamines and anilines to give 1,1-diamino-2,2-dinitroethylenes in excellent yield. Cyclic products are obtained from the reaction of 1,1-diiododinitroethylene with 1,2-diaminoethane (ethylenediamine), 1,3-diaminopropane and 1,4-diaminobutane. The spirocycle (184) is synthesized from the reaction of 1,1-diiododinitroethylene (183) with 2,2-bis(methylamino)-l,3-diaminopropane. 

Sulfur Bake. The yellow, orange, and brown sulfur dyes belong to this group. The dyes are usually made from aromatic amines, diamines, and their acyl and nuclear alkyl derivatives. These may be used in admixture with nitroanilines and nitrophenols or aminophenols to give the desired shade. The color formed is said to be the result of the formation of the thiazole chromophore, evident in dye structure (1). 

Hydroxide Hydroxide amine diamine Reagent Reagent... 

Amines/diamines have both surfactant and biostatic properties and are therefore particularly useful for systems that are subject to fouling. 

The applications of re-acidic chiral stationary phases include the resolution of a-blockers and /1-blockers, amines, arylacetamine, alkylcarbinols, hydantoins, barbiturates, naphthols, benzodiazapines, carboxylic acids, lactams, lactones, phthaldehydes selenoids, and phosphorus compounds. Hyun et al. [16] achieved a chiral resolution of a homologous series of iV-acyl-x-(l-naphthyl )cthylaminc on AA(3,5-dinitrobenzoyl-(i )-phenylglycine and N-(3,5 - dini tr o ben zoy I)-(,S ) -1 c u c ine CSPs. The authors used hexane-2-propanol (80 20, v/v) as the mobile phase. Similarly, the scope of re-basic CSPs comprises the chiral resolution of / -blockers, amino acids, amines, diamines, amino phosphonates, naphthols, benza-diazapines, carboxylic acids, hydroxy acids, dipeptides, tripeptides, diols,... 

Amine oxidases catalyze the oxidation of amines, diamines, and polyamines. According to their ability to recognize one of those substrates preferentially, amine oxidases may be divided into monoamine oxidases, diamine oxidases, and polyamine oxidases, respectively. Several different enzymes fall into the amine oxidase class, and the classification of some of them still remains ambiguous. The term monoamine oxidase (flavin-containing, EC 1.4.3.4) was introduced to contrast with copper-containing amine oxidases (EC 1.4.3.6). 

Figure 8.27 Electropherogram of glucosamine and a mixture of amines, diamines, and amino acids at pH 9.78 [169].

The rather selective structure-template relationship of AlPOi,-20 and AlP0i,-17 contrasts with the large number of templates that make AlP0i,-5 (Figure 12). Among these templates are quaternary ammonium cations, primary amines, secondary amines, tertiary amines, cyclic amines, diamines, and alkanolamines. Individual templates contain as many as 13 C+N atoms to as few as 5. There seems to be no common thread connecting these templates, not size, not shape, not solubility, and not pKjj. 

Metal rf-inline complexes with various transition metals [1-10] and lanthanides [11,12] are well known in the literature. Early transition metal if-imine complexes have attracted attention as a-amino carbanion equivalents. Zirconium rf-imine complexes, or zirconaaziridines (the names describe different resonance structures), are readily accessible and have been applied in organic synthesis in view of the umpolung [13] of their carbons whereas imines readily react with nucleophiles, zirconaaziridines undergo the insertion of electrophilic reagents. Accessible compounds include heterocycles and nitrogen-containing products such as allylic amines, diamines, amino alcohols, amino amides, amino am-idines, and amino acid esters. Asymmetric syntheses of allylic amines and a-amino acid esters have even been carried out. The mechanism of such transformations has implications not only for imine complexes, but also for the related aldehyde and ketone complexes [14-16]. The synthesis and properties of zirconaaziridines and their applications toward organic transformations will be discussed in this chapter. 

Fig. 7. Fraction of amine, diamine and diepoxide units with different number of reacted functionalities...

The use of im-butyl /V./V-dichlorocarbamate allows the preparation of the corresponding A -Boc-protcctcd amines, from which the free amines can be conveniently obtained by mild acidic treatment. The addition to indene, and 1,2-dihydronaphthalene and benzopyran derivatives gave exclusively the tram-adducts, from which amines, diamines, aziridines, and oxazo-lidinones were in turn prepared79. 

Bryantsev, V.S., Diallo, M.S., Goddard, W.A. pK(a) calculations of aliphatic amines, diamines, and aminoamides via density functional theory with a Poisson-Boltzmann continuum solvent model. J. Phys. Chem. A 2007,111(20), 4422-30. 

Although prochiral or chiral alcohols and carboxylic acid esters initially served as the primary classes of substrates, compounds susceptible to processing via these two routes now encompass diols, a- and 3-hydroxy acids, cyanohydrins, chlorohydrins, diesters, lactones, amines, diamines, amino alcohols, and a-and 3-amino acid derivatives. Gotor and Arroyo have reviewed the use of biocatalysts for the preparation of pharma-eeutical intermediates and fine ehemieals. Some specific examples are indieated below. 

Wollastonite and kaolin are most frequently modified by silanes. " Several water-borne products are now available for this purpose, including those with functional amines, diamines, and vinyl-amines. ... 

Condensation reactions can be grouped into two categories. The first category involves pyrazol-3-ones with formyl, acyl, nitroso, a,jS-unsaturated oxo, 3-oxo-2-azobutyric acid ethyl ester or acetonitrile substituents at position 4 or formyl substituents at position 5 and their reaction with carbanions, heterocyclic methylcarbenium salts, primary and secondary amines, diamines, heterocyclic perchlorates, hydroxylamine, hydrazines, urea or thiosemicarbazide. The second category involves pyrazol-3-ones with amino, hydrazino, heteroaromatic amino, acetyl or acetonitiilo groups at position 4 and their reaction with aryl or heteroaromatic aldehydes or cyclic ketones. 

The present method eliminates the intermediate preparation of diborane or ammonium salts, and does not require elevated temperatures, as in transamination. The concomitant risk of amino-borane formation is thus avoided. Finally, the present method generally produces high yields or pure product with ammonia, primary, secondary, or tertiary amines, diamines, and with phosphines from readily available starting materials in conventional apparatus.9... 

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